1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

SB-399885 hydrochloride 

Cat. No.: HY-103099 Purity: 98.93%
Handling Instructions

SB-399885 hydrochloride is a 5-HT6 receptor antagonist.

For research use only. We do not sell to patients.

SB-399885 hydrochloride Chemical Structure

SB-399885 hydrochloride Chemical Structure

CAS No. : 402713-81-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 408 In-stock
Estimated Time of Arrival: December 31
50 mg USD 732 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SB-399885 hydrochloride is a 5-HT6 receptor antagonist.

IC50 & Target

5-HT6 receptor[1]

In Vivo

Compare with the control vehicle SB-399885 hydrochloride 10 mg/kg significantly increases wakefulness (W) (F(3,15)=3.32, P<0.05) while slow wave sleep (SWS), rapid-eye-movement sleep (REMS) and the number of REM periods are reduced (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively). Analysis of sleep variables in 2-h blocks shows that SB-399885 hydrochloride 10 mg/kg increases W (F(3,15)=5.48, P<0.01) and reduces SWS (F(3,15)=5.42, P<0.01) and REMS (F(3,15)= 4.05, P<0.01) during the first 2-h period. SB-399885 hydrochloride 5 and 10 mg/kg augment light sleep over the first (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01, respectively) and the second (F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively) 2-h recording periods. SB-399885 hydrochloride 10 mg/kg significantly increases REMS latency (F(3,15)=3.60, P<0.01) and reduces the number of REM periods during the first 2-h of recording (F(3,15)=3.88, P<0.01)[1].

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (258.90 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0712 mL 10.3560 mL 20.7121 mL
5 mM 0.4142 mL 2.0712 mL 4.1424 mL
10 mM 0.2071 mL 1.0356 mL 2.0712 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Twelve male Wistar rats weighing 350 to 400 g at the time of surgery are used. SB-399885 hydrochloride 2.5, 5 and 10 mg/kg or vehicle (1% aqueous solution of Tween 80) (n=6) are administered intraperitoneally in animals adapted to a 12 h dark/12 h light cycle for 4 weeks, starting 2 h after the beginning of the dark period. Each animal receives all 12 treatments. Recordings are begun 15 min later and continued for 6 h. The control solution and SB-399885 hydrochloride are given at least three days apart[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

482.81

Formula

C₁₈H₂₂Cl₃N₃O₄S

CAS No.

402713-81-9

SMILES

O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Cl)=CC(Cl)=C3OC)=O.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SB-399885 hydrochloride
Cat. No.:
HY-103099
Quantity:

SB-399885 hydrochloride

Cat. No.: HY-103099