1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB-269970 hydrochloride

SB-269970 hydrochloride  (Synonyms: SB-269970A)

Cat. No.: HY-15370A Purity: 99.15%
COA Handling Instructions

SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors.

For research use only. We do not sell to patients.

SB-269970 hydrochloride Chemical Structure

SB-269970 hydrochloride Chemical Structure

CAS No. : 261901-57-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 191 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 191 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 174 In-stock
Estimated Time of Arrival: December 31
50 mg USD 576 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of SB-269970 hydrochloride:

Top Publications Citing Use of Products

2 Publications Citing Use of MCE SB-269970 hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors[1][2].

IC50 & Target

5-HT7 Receptor

8.3 (pKi)

In Vivo

SB269970 hydrochloride (SB-269970A) (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL6/J mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly blocked amphetamine and ketamine-induced hyperactivity.
Molecular Weight

388.95

Formula

C18H29ClN2O3S

CAS No.
SMILES

OC1=CC=CC(S(=O)(N2[[email protected]@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (77.13 mM)

H2O : 10 mg/mL (25.71 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5710 mL 12.8551 mL 25.7102 mL
5 mM 0.5142 mL 2.5710 mL 5.1420 mL
10 mM 0.2571 mL 1.2855 mL 2.5710 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (25.71 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.15%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SB-269970 hydrochloride
Cat. No.:
HY-15370A
Quantity:
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