SB-269970 hydrochloride
Based on 7 publication(s) in Google Scholar
SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 261901-57-9
- Formula: C18H29ClN2O3S
- Molecular Weight:388.95
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SB-269970 hydrochloride
More- Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
- Protein Cell. 2019 Mar;10(3):178-195. [Abstract]
- Neuron. 2025 Apr 10:S0896-6273(25)00220-X. [Abstract]
- Cancer Lett. 2024 Sep 28:600:217150. [Abstract]
- Int J Biol Sci. 2024 Aug 19;20(11):4476-4495. [Abstract]
- J Physiol. 2025 Sep;603(17):4723-4745. [Abstract]
- Authorea. September 19, 2022.
Customer Validation & Images
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In Vivo Efficacy Study
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WB
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IF
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WB
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WB
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT7 Receptor |
5-HT7 Receptor 8.3 (pKi) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL6/J mice[1]
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Dosage:3, 10, 30 mg/kg
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Administration:Intraperitoneal injection; once
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Result:Significantly blocked amphetamine and ketamine-induced hyperactivity.
Chemical Information
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CAS No. 261901-57-9
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Appearance Solid
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Molecular Weight 388.95
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Formula C18H29ClN2O3S
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Color White to off-white
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SMILES
OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl
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Synonyms
SB-269970A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Cell Metab
Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. [Abstract]2025 Dec 17:S1550-4131(25)00495-4. PMID: 41412121 -
Protein Cell
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]2019 Mar;10(3):178-195. PMID: 29542010 -
Neuron
2025 Apr 10:S0896-6273(25)00220-X. PMID: 40233747 -
Cancer Lett
Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer. [Abstract]2024 Sep 28:600:217150. PMID: 39097134
SB-269970 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Sep 28:600:217150. [Abstract]
SB-269970 Hydrochloride (SB269970; 5 mg/kg; IP; daily) failed to suppress the growth of shTph1 MC38 tumors in C57BL/6J mice.
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Int J Biol Sci
Chronic Stress-induced Serotonin Impairs Intestinal Epithelial Cell Mitochondrial Biogenesis via the AMPK-PGC-1α Axis. [Abstract]2024 Aug 19;20(11):4476-4495. PMID: 39247815
SB-269970 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Aug 19;20(11):4476-4495. [Abstract]
SB-269970 Hydrochloride (SB269970; 10 μM; 1+24 h) essentially reversed the 5-HT-induced reduction in AMPK phosphorylation and attenuated the 5-HT-induced down-regulation of PGC-1α, TFAM, and VDAC induced by 5-HT in HT-29 cells.
SB-269970 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Aug 19;20(11):4476-4495. [Abstract]
SB-269970 Hydrochloride (SB269970; 30 mg/kg; IP; daily) rescued the reduction in goblet cells in the colon of CRS mice.
SB-269970 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Aug 19;20(11):4476-4495. [Abstract]
SB-269970 Hydrochloride (SB269970; 30 mg/kg; IP; daily) rescued the expression of occludin, claudin-1 and claudin-3 in the colon of CRS mice.
SB-269970 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Aug 19;20(11):4476-4495. [Abstract]
SB-269970 Hydrochloride (SB269970; 30 mg/kg; IP; daily) alleviated the reduction in p-AMPK (T172) levels in the colon of CRS mice, as well as the expression of PGC-1α, TFAM, and VDAC in the colon of CRS mice.
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J Physiol
5-HT7 antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity. [Abstract]2025 Sep;603(17):4723-4745. PMID: 40757652 -
Solvent & Solubility
DMSO : ≥ 100 mg/mL (257.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 10 mg/mL (25.71 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (25.71 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. http://www.ncbi.nlm.nih.gov/pubmed/10821781 [Content Brief]
[2]. Roberts C, et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol. 2001 Apr;132(7):1574-80. [Content Brief]
[3]. Monti JM, et al. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behav Brain Res. 2008 Aug 22;191(2):184-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5710 mL | 12.8551 mL | 25.7102 mL | 64.2756 mL |
| 5 mM | 0.5142 mL | 2.5710 mL | 5.1420 mL | 12.8551 mL | |
| 10 mM | 0.2571 mL | 1.2855 mL | 2.5710 mL | 6.4276 mL | |
| 15 mM | 0.1714 mL | 0.8570 mL | 1.7140 mL | 4.2850 mL | |
| 20 mM | 0.1286 mL | 0.6428 mL | 1.2855 mL | 3.2138 mL | |
| 25 mM | 0.1028 mL | 0.5142 mL | 1.0284 mL | 2.5710 mL | |
| DMSO | 30 mM | 0.0857 mL | 0.4285 mL | 0.8570 mL | 2.1425 mL |
| 40 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6069 mL | |
| 50 mM | 0.0514 mL | 0.2571 mL | 0.5142 mL | 1.2855 mL | |
| 60 mM | 0.0429 mL | 0.2143 mL | 0.4285 mL | 1.0713 mL | |
| 80 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8034 mL | |
| 100 mM | 0.0257 mL | 0.1286 mL | 0.2571 mL | 0.6428 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SB-269970 hydrochloride Related Classifications
HY-15370A Related Classifications
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