1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB-269970 hydrochloride

SB-269970 hydrochloride (Synonyms: SB-269970A)

Cat. No.: HY-15370A Purity: 98.77%
Handling Instructions

SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.

For research use only. We do not sell to patients.

SB-269970 hydrochloride Chemical Structure

SB-269970 hydrochloride Chemical Structure

CAS No. : 261901-57-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 191 In-stock
Estimated Time of Arrival: December 31
10 mg USD 174 In-stock
Estimated Time of Arrival: December 31
50 mg USD 576 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SB-269970 hydrochloride:

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Description

SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.

IC50 & Target

pKi: 8.3 (5-HT7 receptor)[1]

In Vivo

SB269970 hydrochloride (SB-269970A) (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2].

Animal Model: Male C57BL6/J mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly blocked amphetamine and ketamine-induced hyperactivity.
Molecular Weight

388.95

Formula

C₁₈H₂₉ClN₂O₃S

CAS No.

261901-57-9

SMILES

OC1=CC=CC(S(=O)(N2[[email protected]@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (77.13 mM)

H2O : 10 mg/mL (25.71 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5710 mL 12.8551 mL 25.7102 mL
5 mM 0.5142 mL 2.5710 mL 5.1420 mL
10 mM 0.2571 mL 1.2855 mL 2.5710 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.77%

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Keywords:

SB-269970SB-269970ASB269970SB 2699705-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product name:
SB-269970 hydrochloride
Cat. No.:
HY-15370A
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