1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB-269970

SB-269970 

Cat. No.: HY-15370
Handling Instructions

SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.

For research use only. We do not sell to patients.

SB-269970 Chemical Structure

SB-269970 Chemical Structure

CAS No. : 201038-74-6

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Description

SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.

IC50 & Target

Human 5-HT7 Receptor

8.3 (pKi)

In Vivo

SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male C57BL6/J mice[2]
Dosage: 3, 10, 30 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly blocked amphetamine and ketamine-induced hyperactivity.
Molecular Weight

352.49

Formula

C₁₈H₂₈N₂O₃S

CAS No.

201038-74-6

SMILES

OC1=CC=CC(S(=O)(N2[[email protected]@H](CCN3CCC(C)CC3)CCC2)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SB-269970SB269970SB 2699705-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product Name:
SB-269970
Cat. No.:
HY-15370
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