201038-74-6
201038-74-6
Chemical Structure
SB-269970
- CAS No.: 201038-74-6
- Formula:C18H28N2O3S
- Molecular Weight:352.49
IUPAC Name: (R)-3-((2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol
InChIKey: HWKROQUZSKPIKQ-MRXNPFEDSA-N
SMILES: OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1
Biological Activity: SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB-269970 | 99.84% | SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors. | ||||||||||||||||||||
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References
- [1]. Hagan JJ, et al. Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Br J Pharmacol. 2000 Jun;130(3):539-48. [Content Brief]
- [2]. Roberts C, et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol. 2001 Apr;132(7):1574-80. [Content Brief]
