1. Neuronal Signaling
  2. Serotonin Transporter
  3. Duloxetine hydrochloride

Duloxetine hydrochloride (Synonyms: (S)-Duloxetine hydrochloride; LY-248686 hydrochloride)

Cat. No.: HY-B0161A Purity: 99.92%
Handling Instructions

Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

For research use only. We do not sell to patients.

Duloxetine hydrochloride Chemical Structure

Duloxetine hydrochloride Chemical Structure

CAS No. : 136434-34-9

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
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50 mg USD 95 In-stock
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100 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

In Vitro

Duloxetine ((S)-Duloxetine hydrochloride) (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia. The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications[1][2].

Clinical Trial
Molecular Weight

333.88

Formula

C₁₈H₂₀ClNOS

CAS No.

136434-34-9

SMILES

CNCC[[email protected]](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (299.51 mM)

H2O : 5 mg/mL (14.98 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9951 mL 14.9754 mL 29.9509 mL
5 mM 0.5990 mL 2.9951 mL 5.9902 mL
10 mM 0.2995 mL 1.4975 mL 2.9951 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Duloxetine(S)-DuloxetineLY-248686LY248686LY 248686Serotonin Transporter5-HTTSERTSLC6A4depressivedisordergeneralizedanxietyosteoarthiritismusculoskeletalpainInhibitorinhibitorinhibit

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Product name:
Duloxetine hydrochloride
Cat. No.:
HY-B0161A
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