(R)-Duloxetine
(R)-Duloxetine is a isomer of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research.
For research use only. We do not sell to patients.
- CAS No.: 116539-60-7
- Formula: C18H19NOS
- Molecular Weight:297.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
13.2 nM
Compound: 10a
|
Inhibition of [3H]NE reuptake at human NET expressed in HEK cells
Inhibition of [3H]NE reuptake at human NET expressed in HEK cells
|
[PMID: 19740668] |
| HEK293 | IC50 |
2.6 nM
Compound: 10a
|
Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cells
Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cells
|
[PMID: 19740668] |
| HEK293 | IC50 |
809 nM
Compound: 10a
|
Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cells
Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cells
|
[PMID: 19740668] |
Chemical Information
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CAS No. 116539-60-7
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Molecular Weight 297.41
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Formula C18H19NOS
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SMILES
CNCC[C@@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3
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Synonyms
(R)-LY248686
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)