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Art. -Nr.: HY-B0161C

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(R)-Duloxetine

(Synonyms: (R)-LY248686)

(R)-Duloxetine is a isomer of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na⁺ channels. (R)-Duloxetine can be used in pain research.

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CAS. Nr.: 116539-60-7
Formel: C₁₈H₁₉NOS
Molecular Weight:297.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(R)-Duloxetine Chemical Structure

CAS. Nr.: 116539-60-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-B0161CR

(R)-Duloxetine (Standard)

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(R)-Duloxetine is a isomer of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na⁺ channels. (R)-Duloxetine can be used in pain research^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	13.2 nM Compound: 10a	Inhibition of [3H]NE reuptake at human NET expressed in HEK cells Inhibition of [3H]NE reuptake at human NET expressed in HEK cells	[PMID: 19740668]
HEK293	IC₅₀	2.6 nM Compound: 10a	Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cells Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cells	[PMID: 19740668]
HEK293	IC₅₀	809 nM Compound: 10a	Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cells Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cells	[PMID: 19740668]

Chemical Information

CAS. Nr. 116539-60-7
Molecular Weight 297.41
Formel C₁₈H₁₉NOS
SMILES

CNCC[C@@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3
Synonyms

(R)-LY248686
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang CF, et al. R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. Anesth Analg. 2016 Mar;122(3):719-729. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

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(R)-Duloxetine

(R)-Duloxetine (Standard)

Alle Sodium Channel Isoform-spezifische Produkte anzeigen