116539-60-7
Chemical Structure
(R)-Duloxetine
Synonym(s): (R)-LY248686
- CAS No.: 116539-60-7
- Formula:C18H19NOS
- Molecular Weight:297.41
IUPAC Name: (R)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
InChIKey: ZEUITGRIYCTCEM-QGZVFWFLSA-N
SMILES: CNCC[C@@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3
Biological Activity: (R)-Duloxetine ((R)-LY248686) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine blocks Na+ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine can be used for research on postoperative (post-incisional) pain[1].
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(R)-Duloxetine | (R)-Duloxetine ((R)-LY248686) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine blocks Na+ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine can be used for research on postoperative (post-incisional) pain. | |||||||||||||||||||||
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(R)-Duloxetine (Standard) | ≥98% | (R)-Duloxetine (Standard) ((R)-LY248686 (Standard)) is the analytical standard of (R)-Duloxetine (HY-B0161C). This product is intended for research and analytical applications. (R)-Duloxetine ((R)-LY248686) is a neuronal voltage-gated sodium channel blocker with analgesic activity. (R)-Duloxetine blocks Na+ currents with higher affinity for the inactivated state than for the resting state. (R)-Duloxetine alleviates postoperative mechanical allodynia and hyperalgesia. (R)-Duloxetine exerts its effects through a local peripheral mechanism of action. (R)-Duloxetine can be used for research on postoperative (post-incisional) pain. | ||||||||||||||||||||
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