1. Neuronal Signaling
  2. Serotonin Transporter
  3. Fluvoxamine

Fluvoxamine (Synonyms: DU-23000)

Cat. No.: HY-B0103
Handling Instructions

Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

For research use only. We do not sell to patients.

Fluvoxamine Chemical Structure

Fluvoxamine Chemical Structure

CAS No. : 54739-18-3

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Description

Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

IC50 & Target

SSRIs[1].

In Vivo

Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine[1]. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted[2]. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement[3].

Clinical Trial
Molecular Weight

318.33

Formula

C₁₅H₂₁F₃N₂O₂

CAS No.

54739-18-3

SMILES

FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FluvoxamineDU-23000DU23000DU 23000Serotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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Fluvoxamine
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HY-B0103
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