1. Neuronal Signaling
  2. Serotonin Transporter
  3. Fluvoxamine maleate

Fluvoxamine maleate (Synonyms: DU-23000 (maleate))

Cat. No.: HY-B0103A Purity: 99.85%
Handling Instructions

Fluvoxamine (maleate) (DU-23000 (maleate)) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

For research use only. We do not sell to patients.

Fluvoxamine maleate Chemical Structure

Fluvoxamine maleate Chemical Structure

CAS No. : 61718-82-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 96 In-stock
Estimated Time of Arrival: December 31
100 mg USD 144 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

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Description

Fluvoxamine (maleate) (DU-23000 (maleate)) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

IC50 & Target

SSRIs[1].

In Vivo

Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine[1]. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted[2]. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement[3].

Clinical Trial
Molecular Weight

434.41

Formula

C₁₉H₂₅F₃N₂O₆

CAS No.

61718-82-9

SMILES

O=C(O)/C=C\C(O)=O.FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (230.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3020 mL 11.5099 mL 23.0197 mL
5 mM 0.4604 mL 2.3020 mL 4.6039 mL
10 mM 0.2302 mL 1.1510 mL 2.3020 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.75 mM); Clear solution

  • 4.

    Add each solvent one by one:  phosphate buffer saline

    Solubility: 20 mg/mL (46.04 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

FluvoxamineDU-23000DU23000DU 23000Serotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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Product name:
Fluvoxamine maleate
Cat. No.:
HY-B0103A
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