2. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. Mineralocorticoid Receptor
  4. Finerenone

Finerenone  (Synonyms: BAY 94-8862)

Cat. No.: HY-111372 Purity: 99.95% ee.: 100%
COA Handling Instructions

Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

For research use only. We do not sell to patients.

Finerenone Chemical Structure

Finerenone Chemical Structure

CAS No. : 1050477-31-0

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Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 720 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Finerenone:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Finerenone

RT-PCR

    Finerenone purchased from MCE. Usage Cited in: Nature. 2023 Feb;614(7947):326-333.  [Abstract]

    Finerenone (1 μM; 24 h) increases Il6, Il1b, and Ccl2 gene expression in primary mouse astrocytes activated in vitro with 1 ng/mL of IL-1β and TNFα, and (1 μM; 4 h) also boosts Xbp1 splicing.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease[1][2].

    In Vivo

    Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Frömter (MWF) rat[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Twelve-week-old MWF rat[1]
    Dosage: 10 mg/kg
    Administration: P.o.; daily for 4 weeks
    Result: Significantly reduced SBP in MWF rats; led to a significant reduction (>40%) in albuminuria in the MWF model.
    Animal Model: Twelve-week-old MWF rat[1]
    Dosage: 10 mg/kg
    Administration: P.o.; daily for 4 weeks
    Result: Significantly reduced SBP in MWF rats; led to a significant reduction (>40%) in albuminuria in the MWF model.
    Clinical Trial
    Molecular Weight

    378.42

    Appearance

    Solid

    Formula

    C21H22N4O3
    CAS No.
    SMILES

    O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[[email protected]@H]1C3=CC=C(C#N)C=C3OC)N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 200 mg/mL (528.51 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6426 mL 13.2128 mL 26.4257 mL
    5 mM 0.5285 mL 2.6426 mL 5.2851 mL
    10 mM 0.2643 mL 1.3213 mL 2.6426 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1.93 mg/mL (5.10 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 1.93 mg/mL (5.10 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.95% ee.: 100%

    COA (251 KB) HNMR (504 KB) NP-HPLC (369 KB) LCMS (109 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Finerenone1050477-31-0BAY 94-8862Mineralocorticoid Receptortype2diabeteschronickidneydiseasesystolicbloodpressureoralnonsteroidalcardiorenalInhibitorinhibitorinhibit

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