2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Mineralocorticoid Receptor
  4. Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

For research use only. We do not sell to patients.

Finerenone-d<sub>3</sub>

Finerenone-d3 Chemical Structure

CAS No. : 2917530-37-9

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Other Forms of Finerenone-d3:

Finerenone-d3 Related Antibodies

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Description

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease[1][2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Molecular Weight

381.44

Formula

C21H19D3N4O3
CAS No.
Unlabeled CAS
Appearance

Solid

SMILES

O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[C@@H]1C3=CC=C(C#N)C=C3OC([2H])([2H])[2H])N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (262.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6216 mL 13.1082 mL 26.2164 mL
5 mM 0.5243 mL 2.6216 mL 5.2433 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6216 mL 13.1082 mL 26.2164 mL 65.5411 mL
5 mM 0.5243 mL 2.6216 mL 5.2433 mL 13.1082 mL
10 mM 0.2622 mL 1.3108 mL 2.6216 mL 6.5541 mL
15 mM 0.1748 mL 0.8739 mL 1.7478 mL 4.3694 mL
20 mM 0.1311 mL 0.6554 mL 1.3108 mL 3.2771 mL
25 mM 0.1049 mL 0.5243 mL 1.0487 mL 2.6216 mL
30 mM 0.0874 mL 0.4369 mL 0.8739 mL 2.1847 mL
40 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6385 mL
50 mM 0.0524 mL 0.2622 mL 0.5243 mL 1.3108 mL
60 mM 0.0437 mL 0.2185 mL 0.4369 mL 1.0924 mL
80 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8193 mL
100 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.6554 mL
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Finerenone-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Finerenone-d32917530-37-9BAY 94-8862-d3Mineralocorticoid ReceptorIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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