2. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. Mineralocorticoid Receptor
  4. (Rac)-Finerenone

(Rac)-Finerenone  (Synonyms: (Rac)-BAY 94-8862)

Cat. No.: HY-111372A Purity: 99.66%
COA Handling Instructions

(Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).

For research use only. We do not sell to patients.

(Rac)-Finerenone Chemical Structure

(Rac)-Finerenone Chemical Structure

CAS No. : 1050477-27-4

Size Price Stock
Solution
10 mM * 1 mL in DMSO USD 330 Ask For Quote & Lead Time
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 330 Ask For Quote & Lead Time
Solid
5 mg USD 300 Ask For Quote & Lead Time

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Description

(Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold)[1].

Molecular Weight

378.42

Appearance

Solid

Formula

C21H22N4O3
CAS No.
SMILES

N#CC(C=C1OC)=CC=C1C2C3=C(C(C)=CN=C3OCC)NC(C)=C2C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (165.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6426 mL 13.2128 mL 26.4257 mL
5 mM 0.5285 mL 2.6426 mL 5.2851 mL
10 mM 0.2643 mL 1.3213 mL 2.6426 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.66%

COA (251 KB) HNMR (280 KB) LCMS (101 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(Rac)-Finerenone1050477-27-4(Rac)-BAY 94-8862Mineralocorticoid ReceptorInhibitorinhibitorinhibit

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