2. Others Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Drug Isomer Mineralocorticoid Receptor
  4. (R)-Finerenone

(R)-Finerenone ((R)-BAY 94-8862) is the R-isomer of Finerenone (HY-111372). Finerenone is a third-generation selective, orally active, non-steroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Compared with glucocorticoid receptors (GR), androgen receptors (AR), and progesterone receptors (AR), Finerenone shows good selectivity (> 500-fold). Finerenone has potential application prospects in studies of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease.

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(R)-Finerenone

(R)-Finerenone Chemical Structure

CAS No. : 1050477-30-9

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Other Forms of (R)-Finerenone:

(R)-Finerenone Related Antibodies

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Description

(R)-Finerenone ((R)-BAY 94-8862) is the R-isomer of Finerenone (HY-111372). Finerenone is a third-generation selective, orally active, non-steroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Compared with glucocorticoid receptors (GR), androgen receptors (AR), and progesterone receptors (AR), Finerenone shows good selectivity (> 500-fold). Finerenone has potential application prospects in studies of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease[1][2].

Molecular Weight

378.42

Formula

C21H22N4O3
CAS No.
SMILES

O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[C@H]1C3=CC=C(C#N)C=C3OC)N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6426 mL 13.2128 mL 26.4257 mL
5 mM 0.5285 mL 2.6426 mL 5.2851 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6426 mL 13.2128 mL 26.4257 mL 66.0642 mL
5 mM 0.5285 mL 2.6426 mL 5.2851 mL 13.2128 mL
10 mM 0.2643 mL 1.3213 mL 2.6426 mL 6.6064 mL
15 mM 0.1762 mL 0.8809 mL 1.7617 mL 4.4043 mL
20 mM 0.1321 mL 0.6606 mL 1.3213 mL 3.3032 mL
25 mM 0.1057 mL 0.5285 mL 1.0570 mL 2.6426 mL
30 mM 0.0881 mL 0.4404 mL 0.8809 mL 2.2021 mL
40 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6516 mL
50 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3213 mL
60 mM 0.0440 mL 0.2202 mL 0.4404 mL 1.1011 mL
80 mM 0.0330 mL 0.1652 mL 0.3303 mL 0.8258 mL
100 mM 0.0264 mL 0.1321 mL 0.2643 mL 0.6606 mL
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(R)-Finerenone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Finerenone1050477-30-9(R)-BAY 94-8862Drug IsomerMineralocorticoid ReceptorInhibitorinhibitorinhibit

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