1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor
    Endogenous Metabolite
  3. 18-Oxocortisol

18-Oxocortisol 

Cat. No.: HY-113151
Handling Instructions

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.

For research use only. We do not sell to patients.

18-Oxocortisol Chemical Structure

18-Oxocortisol Chemical Structure

CAS No. : 2410-60-8

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Description

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].

In Vivo

Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].

Molecular Weight

376.44

Formula

C₂₁H₂₈O₆

CAS No.

2410-60-8

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

18-OxocortisolMineralocorticoid ReceptorEndogenous MetabolitebiomarkernaturallyderivativeCYP11B2aldosteronismhybridbloodpressureInhibitorinhibitorinhibit

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18-Oxocortisol
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HY-113151
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