2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Mineralocorticoid Receptor Endogenous Metabolite
  4. 18-Oxocortisol

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.

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18-Oxocortisol Chemical Structure

18-Oxocortisol Chemical Structure

CAS No. : 2410-60-8

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Based on 1 publication(s) in Google Scholar

18-Oxocortisol Related Antibodies

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Description

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].

In Vivo

Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

376.44

Formula

C21H28O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1CC[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@](C(CO)=O)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (253 KB)

Handling Instructions (2659 KB)
References
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18-Oxocortisol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

18-Oxocortisol2410-60-8Mineralocorticoid ReceptorEndogenous MetabolitebiomarkernaturallyderivativeCYP11B2aldosteronismhybridbloodpressureInhibitorinhibitorinhibit

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