2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy
  3. Mineralocorticoid Receptor Autophagy
  4. Fludrocortisone acetate

Fludrocortisone acetate  (Synonyms: 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate)

Cat. No.: HY-B1203A Purity: 99.37%
COA Handling Instructions

Molarity Calculator

Fludrocortisone acetate (9α-Fludrocortisone acetate) is a synthetic mineralocorticoid with potential use in Addison's disease to reduce urinary sodium loss and to increase blood pressure.

For research use only. We do not sell to patients.

Fludrocortisone acetate Chemical Structure

Fludrocortisone acetate Chemical Structure

CAS No. : 514-36-3

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Fludrocortisone acetate:

Fludrocortisone acetate Related Antibodies

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Description

Fludrocortisone acetate (9α-Fludrocortisone acetate) is a synthetic mineralocorticoid with potential use in Addison's disease to reduce urinary sodium loss and to increase blood pressure.

Clinical Trial
Molecular Weight

422.49

Formula

C23H31FO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (118.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3669 mL 11.8346 mL 23.6692 mL
5 mM 0.4734 mL 2.3669 mL 4.7338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.37%

COA (252 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3669 mL 11.8346 mL 23.6692 mL 59.1730 mL
5 mM 0.4734 mL 2.3669 mL 4.7338 mL 11.8346 mL
10 mM 0.2367 mL 1.1835 mL 2.3669 mL 5.9173 mL
15 mM 0.1578 mL 0.7890 mL 1.5779 mL 3.9449 mL
20 mM 0.1183 mL 0.5917 mL 1.1835 mL 2.9586 mL
25 mM 0.0947 mL 0.4734 mL 0.9468 mL 2.3669 mL
30 mM 0.0789 mL 0.3945 mL 0.7890 mL 1.9724 mL
40 mM 0.0592 mL 0.2959 mL 0.5917 mL 1.4793 mL
50 mM 0.0473 mL 0.2367 mL 0.4734 mL 1.1835 mL
60 mM 0.0394 mL 0.1972 mL 0.3945 mL 0.9862 mL
80 mM 0.0296 mL 0.1479 mL 0.2959 mL 0.7397 mL
100 mM 0.0237 mL 0.1183 mL 0.2367 mL 0.5917 mL
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Fludrocortisone acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fludrocortisone514-36-39α-Fludrocortisone9α-FluorcortisolMineralocorticoid ReceptorAutophagyInhibitorinhibitorinhibit

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