514-36-3
514-36-3
Chemical Structure
Fludrocortisone acetate
Synonym(s): 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate
- CAS No.: 514-36-3
- Formula:C23H31FO6
- Molecular Weight:422.49
IUPAC Name: 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
InChIKey: SYWHXTATXSMDSB-GSLJADNHSA-N
SMILES: C[C@@]12[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Biological Activity: Fludrocortisone acetate (9α-Fludrocortisone acetate) is an orally active synthetic mineralocorticoid. Fludrocortisone acetate can effectively control sodium retention. Fludrocortisone acetate is used in studies of cardiac injury, adrenal insufficiency and orthostatic hypotension[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fludrocortisone acetate | 99.59% | Fludrocortisone acetate (9α-Fludrocortisone acetate) is an orally active synthetic mineralocorticoid. Fludrocortisone acetate can effectively control sodium retention. Fludrocortisone acetate is used in studies of cardiac injury, adrenal insufficiency and orthostatic hypotension. | ||||||||||||||||||||
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Fludrocortisone acetate (Standard) | 98.48% | Fludrocortisone acetate (Standard) is the analytical standard of Fludrocortisone acetate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Fludrocortisone acetate-d5 | 97.89% | Fludrocortisone acetate-d5 is deuterium labeled Fludrocortisone acetate. | ||||||||||||||||||||
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Fluorogestone acetate | 99.23% | Fluorogestone acetate is a progesterone compound. Fluorogestone acetate inhibits ovulation and synchronizes the estrous cycle in cattle by inhibiting the release of luteinizing hormone (LH) from the pituitary gland. | ||||||||||||||||||||
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Isoflupredone acetate | 98.06% | Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.. | ||||||||||||||||||||
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Dexamethasone acetate | 99.86% | Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery. | ||||||||||||||||||||
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Hydrocortisone acetate (Standard) | ≥98% | Hydrocortisone acetate (Standard) is the analytical standard of Hydrocortisone acetate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Fludrocortisone (Standard) | ≥98% | Fludrocortisone (Standard) (9α-Fludrocortisone (Standard)) is the analytical standard of Fludrocortisone (HY-B1203). This product is intended for research and analytical applications. Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency. | ||||||||||||||||||||
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Betamethasone dipropionate impurity 7 | Betamethasone dipropionate impurity 7 is an impurity of Betamethasone dipropionate. | |||||||||||||||||||||
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Hydrocortisone aceate impurity 1 | Hydrocortisone aceate impurity 1 is an impurity of Hydrocortisone aceate. | |||||||||||||||||||||
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1,2-Dihydro dexamethasone | 1,2-Dihydro dexamethasone is a Dexamethasone (HY-14648) impurity. | |||||||||||||||||||||
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Clobetasol propionate impurity 4 | Clobetasol propionate impurity 4 is an impurity of Clobetasol propionate. | |||||||||||||||||||||
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Dexamethasone impurity 5 | Dexamethasone impurity 5 is an impurity of Dexamethasone. | |||||||||||||||||||||
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References
- [1]. Fitzgerald M, et al. Mineralocorticoids restore quiescent morphology and reduce VEGF receptor expression in inflamed choroidal endothelial cells in vitro. Ophthalmic Res. 2009;41(1):44-52. [Content Brief]
- [2]. Sarker M, et al. Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway. Biomed Pharmacother. 2024 Dec;181:117703. [Content Brief]
- [3]. Djajadiningrat-Laanen SC, et al. Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate. J Vet Intern Med. 2008 Nov-Dec;22(6):1283-8. [Content Brief]
