1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor
  3. Apararenone

Apararenone (Synonyms: MT-3995)

Cat. No.: HY-109002 Purity: 98.80%
Handling Instructions

Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

For research use only. We do not sell to patients.

Apararenone Chemical Structure

Apararenone Chemical Structure

CAS No. : 945966-46-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
25 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

IC50 & Target

Mineralocorticoid receptor[1]

In Vivo

Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].

Clinical Trial
Molecular Weight

364.39

Formula

C₁₇H₁₇FN₂O₄S

CAS No.

945966-46-1

SMILES

O=C1N(C2=CC=C(F)C=C2)C3=CC=C(NS(C)(=O)=O)C=C3OC1(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (343.04 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7443 mL 13.7216 mL 27.4431 mL
5 mM 0.5489 mL 2.7443 mL 5.4886 mL
10 mM 0.2744 mL 1.3722 mL 2.7443 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Apararenone
Cat. No.:
HY-109002
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