Agatolimod sodium  (Synonyms: ODN 2006 sodium; ODN 7909 sodium; PF-3512676 sodium; CpG 7909 sodium)

Agatolimod sodium (ODN 2006) is a class B CpG ODN and is a TLR9 agonist. Agatolimod sodium can be used as vaccine adjuvant. Agatolimod sodium can be used for the research of cancer. Sequence: 5’-TCGTCGTTTTGTCGTTTTGTCGTT-3’^[1][2].

Agatolimod sodium (ODN 2006) (10 μg/mL; 24 and 48 h) increases radiation sensitivity of radiation-resistant human lung adenocarcinoma cell line by overexpression of TLR9^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7699 (free acid)

541547-35-7

Solid

White to off-white

DNA, d(P-thio)(T-C-G-T-C-G-T-T-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T)

[Agatolimod (sodium)]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Yan L, et al. CpG-ODN 7909 increases radiation sensitivity of radiation-resistant human lung adenocarcinoma cell line by overexpression of Toll-like receptor 9. Cancer Biother Radiopharm. 2013 Sep;28(7):559-64.  [Content Brief]

  [2]. Cooper CL, et al. Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine. Vaccine. 2004 Aug 13;22(23-24):3136-43.  [Content Brief]