1702809-17-3
1702809-17-3
Chemical Structure
THZ531
- CAS No.: 1702809-17-3
- Formula:C30H32ClN7O2
- Molecular Weight:558.07
IUPAC Name: (R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
InChIKey: RUBYHLPRZRMTJO-MOVYNIQHSA-N
SMILES: ClC(C(C1=CNC2=CC=CC=C12)=N3)=CN=C3N[C@@H]4CCCN(C(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)C4
Biological Activity: THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
THZ531 | 99.23% | THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
THZ531 (Standard) | ≥98% | THZ531 (Standard) is the analytical standard of THZ531 (HY-103618). This product is intended for research and analytical applications. THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.74
HY-145072BSJ-01-175 -
Similarity Score 0.71
HY-128587Mevociclib -
Similarity Score 0.69
HY-80013THZ1 -
Similarity Score 0.68
HY-80013B(E/Z)-THZ1 dihydrochloride -
Similarity Score 0.67
HY-164553ZSQ836 -
Similarity Score 0.65
HY-12280THZ2 -
Similarity Score 0.62
HY-19988THZ1-R -
Similarity Score 0.59
HY-136351THZ-P1-2 -
Similarity Score 0.57
HY-149930YL5084 -
Explore the MedChemAI to find more analogs
