1. Cell Cycle/DNA Damage
  2. CDK
  3. Mevociclib

Mevociclib (Synonyms: SY-1365)

Cat. No.: HY-128587 Purity: 99.27%
Handling Instructions

Mevociclib (SY-1365) is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. Mevociclib exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. Mevociclib possesses anti-tumor activity in hematological and multiple aggressive solid tumors.

For research use only. We do not sell to patients.

Mevociclib Chemical Structure

Mevociclib Chemical Structure

CAS No. : 1816989-16-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 452 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 452 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Mevociclib

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mevociclib (SY-1365) is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. Mevociclib exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. Mevociclib possesses anti-tumor activity in hematological and multiple aggressive solid tumors[1][2].

IC50 & Target[1]

CDK7

 

In Vitro

Mevociclib exhibits inhibition for CDK7/CycH/MAT1 with an IC50 of 20 nM[2].
Mevociclib is a highly selective covalent CDK7 inhibitor, induces apoptosis in leukemia cells, but not in non-malignant cells[2].
Mevociclib exhibits activity in breast, ovarian, colorectal and lung cancer cells that exhibited low nM EC50 and rapid induction of apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mevociclib (20mg/kg; i.v.; biw; for 35 days) inhibits tumor growth in TNBC in vivo models[2].
Mevociclib induces unique transcriptional signature[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice, HCC70 xenograft model[2]
Dosage: 20 mg/kg
Administration: Intravenous injection, twice weekly, for 35 days
Result: Inhibited tumor volume in vivo.
Clinical Trial
Molecular Weight

587.12

Formula

C₃₁H₃₅ClN₈O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (212.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7032 mL 8.5161 mL 17.0323 mL
5 mM 0.3406 mL 1.7032 mL 3.4065 mL
10 mM 0.1703 mL 0.8516 mL 1.7032 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.27%

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Product Name:
Mevociclib
Cat. No.:
HY-128587
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