1. Cell Cycle/DNA Damage
  2. CDK
  3. THZ1-R

THZ1-R 

Cat. No.: HY-19988
COA Handling Instructions

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.

For research use only. We do not sell to patients.

THZ1-R Chemical Structure

THZ1-R Chemical Structure

CAS No. : 1621523-07-6

Size Price Stock Quantity
1 mg USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 462 In-stock
Estimated Time of Arrival: December 31
10 mg USD 726 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2178 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3036 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of THZ1-R:

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.

IC50 & Target[1]

CDK7

146 nM (IC50)

In Vitro

THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

568.07

Formula

C31H30ClN7O2

CAS No.
SMILES

ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(CCCN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (176.03 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7603 mL 8.8017 mL 17.6035 mL
5 mM 0.3521 mL 1.7603 mL 3.5207 mL
10 mM 0.1760 mL 0.8802 mL 1.7603 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.06%

References
Cell Assay
[1]

Cells are seeded in 384-well microplates at 15% confluency in medium with 5% FBS and penicillin/streptavidin. Cells are treated with THZ1 or DMSO for 72 hrs and cell viability is determined using resazurin.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
THZ1-R
Cat. No.:
HY-19988
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