1. Cell Cycle/DNA Damage
  2. CDK
  3. THZ1-R

THZ1-R 

Cat. No.: HY-19988 Purity: 97.96%
Handling Instructions

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.

For research use only. We do not sell to patients.

THZ1-R Chemical Structure

THZ1-R Chemical Structure

CAS No. : 1621523-07-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 525 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2760 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of THZ1-R:

Top Publications Citing Use of Products
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Description

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.

IC50 & Target

IC50: 146 nM (CDK7)[1]

In Vitro

THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1].

Molecular Weight

568.07

Formula

C₃₁H₃₀ClN₇O₂

CAS No.

1621523-07-6

SMILES

ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(CCCN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (176.03 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7603 mL 8.8017 mL 17.6035 mL
5 mM 0.3521 mL 1.7603 mL 3.5207 mL
10 mM 0.1760 mL 0.8802 mL 1.7603 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Cells are seeded in 384-well microplates at 15% confluency in medium with 5% FBS and penicillin/streptavidin. Cells are treated with THZ1 or DMSO for 72 hrs and cell viability is determined using resazurin.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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THZ1-R
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HY-19988
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