ROR2 Protein, Human (Biotinylated, HEK293, His-Avi)

The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

ROR2 protein, a tyrosine-protein kinase receptor, emerges as a key player in the early stages of chondrocyte formation and is deemed essential for cartilage and growth plate development. Its phosphorylation of YWHAB not only induces osteogenesis but also promotes bone formation. Despite exhibiting minimal tyrosine kinase activity in vitro, ROR2's intricate role extends to potentially acting as a receptor for the Wnt ligand WNT5A. This interaction may lead to the intriguing outcome of inhibiting WNT3A-mediated signaling. The multifaceted functions of ROR2 highlight its significance in orchestrating complex processes such as chondrogenesis, osteogenesis, and the intricate regulation of Wnt signaling pathways.

1.This product does not contain protein kinase domain.
2.Immobilized Anti-ROR2 Antibody, hFc Tag at 1 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Human ROR2, hFc Tag with the EC₅₀ of ≤10 ng/mL determined by ELISA.

Human

HEK293

C-Avi;C-8*His

A1L4F5 (V34-G403)

4920

Partial

Biotin

54-65 kDa

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.