ROR2 Protein, Human (HEK293, His-Avi)
The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
ROR2 protein, a tyrosine-protein kinase receptor, emerges as a key player in the early stages of chondrocyte formation and is deemed essential for cartilage and growth plate development. Its phosphorylation of YWHAB not only induces osteogenesis but also promotes bone formation. Despite exhibiting minimal tyrosine kinase activity in vitro, ROR2's intricate role extends to potentially acting as a receptor for the Wnt ligand WNT5A. This interaction may lead to the intriguing outcome of inhibiting WNT3A-mediated signaling. The multifaceted functions of ROR2 highlight its significance in orchestrating complex processes such as chondrogenesis, osteogenesis, and the intricate regulation of Wnt signaling pathways.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-8*His
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Accession
A1L4F5 (E34-G403)
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Gene ID4920
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Molecular Construction
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N-term
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ROR2 (E34-G403)
Accession # A1L4F5 -
8*His-Avi
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C-term
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Protein Length
Partial
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Synonyms
ROR2; Tyrosine-Protein Kinase Transmembrane Receptor ROR2; Prev. NTRKR2; Receptor Tyrosine Kinase-Like Orphan Receptor 2, Isoform CRA_b; Prev. BDB1; Neurotrophic Tyrosine Kinase, Receptor-Related 2; Prev. BDB; Neurotrophic Tyrosine Kinase Receptor-Related
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AA Sequence
EVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMG
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Predicted Molecular Mass
44.2 kDa
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Molecular Weight
Approximately 54-58 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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