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  5. ROR1 Protein, Mouse (HEK293, His)

ROR1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P78032
Handling Instructions

ROR1 protein shows minimal kinase activity in vitro, indicating an improbable role as a tyrosine kinase in vivo. It functions as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Additionally, ROR1 plays a vital role in the inner ear, aiding the innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ROR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ROR1 Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 58-68 kDa.

For research use only. We do not sell to patients.

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Description

ROR1 protein shows minimal kinase activity in vitro, indicating an improbable role as a tyrosine kinase in vivo. It functions as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Additionally, ROR1 plays a vital role in the inner ear, aiding the innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ROR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ROR1 Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 58-68 kDa.

Background

ROR1 protein exhibits very low kinase activity in vitro, suggesting an unlikely role as a tyrosine kinase in vivo. It serves as a receptor for the ligand WNT5A, activating downstream NFkB signaling pathways and potentially inhibiting WNT3A-mediated signaling. Notably, ROR1 plays a crucial role in the inner ear, particularly in facilitating the innervation of auditory hair cells by spiral ganglion neurons.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

Q9Z139 (Q30-Y406)

Gene ID

26563  [NCBI]

Molecular Construction
N-term
ROR1 (Q30-Y406)
Accession # Q9Z139
His
C-term
Synonyms
ROR1; NTRKR1; dJ537F10.1
Molecular Weight

58-68 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
ROR1 Protein, Mouse (HEK293, His)
Cat. No.:
HY-P78032
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