Ror1 - receptor tyrosine kinase-like orphan receptor 1 Gene

Also Known as Ntrkr1; 2810404D04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26563

Summary

This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Ror1 Products (2)

mRNA Protein Name
NM_001312690.1 NP_001299619.1 inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor
NM_013845.5 NP_038873.2 inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in inner ear development IMP
IMP: Inferred from mutant phenotype
27162350 MGI
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
27162350 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive tyrosine-protein kinase transmembrane receptor ROR1

  • neurotrophic tyrosine kinase, receptor-related 1

  • tyrosine-protein kinase transmembrane receptor ROR1

Recombinant Ror1 Proteins

Cat. No. Product Name Accession Purity
HY-P78032 ROR1 Protein, Mouse (HEK293, His) Q9Z139 (Q30-Y406) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99201 Zilovertamab Inhibitor 98.21% Phase 3
HY-P99956 Zilovertamab vedotin Inducer 99.77% Phase 3
HY-P991209 Nebratamig Inhibitor 97.34% Phase 2
HY-P99828 Cofetuzumab 99.31% Phase 1

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139534 ARI-1 99.16% Unkown
HY-126686 Mal-Phe-C4-VC-PAB-MMAE 99.54% Unkown
HY-162640 LDR102 Inhibitor 99.78% Unkown
HY-135319 Strictinin 97.15% Unkown
HY-139534A (S)-ARI-1 Control 99.80% Unkown
HY-160806 (5-Cl)-Exatecan Inhibitor / Unkown
HY-161096 Antitumor agent-127 99.09% Unkown
HY-160806A (5-Cl)-Exatecan TFA Inhibitor / Unkown
HY-117947 (R)-OR-S1 Control / Unkown
HY-170995 PROTAC ROR1 degrader-1 / Unkown
HY-170996 ROR1 ligand-1 Degrader / Unkown
HY-174382 ROR1-IN-3 / Unkown
HY-175497 ROR1-IN-4 / Unkown
HY-176190 ROR1-IN-2 Inhibitor / Unkown
HY-177109 BL20-MMAE Inhibitor / Unkown
HY-183031 BrAA-glycine-BG-PAB-Exatecan / Unkown
HY-P11858 DP1 peptide Ligand / Unkown
HY-P11859 NP1 Ligand / Unkown
HY-RS12124 ROR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12126 RORA Human Pre-designed siRNA Set A / Unkown
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / Unkown
HY-160790 β-Glu-PNP / Unkown
HY-RS16801 Ror1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23242 Ror1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992337 CS5001 Antibody Inhibitor / Unkown
HY-P992376 huXBR1-402 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ror1 NCBI NCBI:4919