2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Antibody-drug Conjugate/ADC Related
  3. ROR Drug-Linker Conjugates for ADC
  4. BL20-MMAE

BL20-MMAE is an antibody-drug conjugate targeting ROR1, which is formed by conjugating an anti-ROR1 antibody with the Auristatin payload MMAE (HY-15162) via a BL20 linker.

For research use only. We do not sell to patients.

BL20-MMAE

BL20-MMAE Chemical Structure

CAS No. : 2765612-38-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

BL20-MMAE Related Antibodies

Top Publications Citing Use of Products

View All ROR Isoform Specific Products:

View All Isoforms
RORγ RORα RORβ

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BL20-MMAE is an antibody-drug conjugate targeting ROR1, which is formed by conjugating an anti-ROR1 antibody with the Auristatin payload MMAE (HY-15162) via a BL20 linker[1].

In Vitro

BL20-MMAE (10 mg/mL; maintained at 28°C, analyzed after conjugation) conjugates with ROR1-4 antibody to form a purified ADC with a precise drug-to-antibody ratio of 4.0[1].
BL20-MMAE (10 mg/mL; maintained at 28°C, analyzed after conjugation) conjugates with ROR1-12 antibody to form a purified ADC with a precise drug-to-antibody ratio of 4.0[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BL20-MMAE Related Antibodies
In Vivo

BL20-MMAE (administered as ROR1-12-BL20E) (5 mg/kg; i.v.; on day 0 and day 4) achieves 92% tumor growth inhibition in JeKo-1 leukemia xenografts, with partial regression observed in 1 of 6 mice[1].
BL20-MMAE (administered as ROR1-12-BL20E) (5 mg/kg; i.v.; once weekly; 3 doses) achieves 49% tumor growth inhibition in MDA-MB-231 breast cancer xenografts[1].
BL20-MMAE (administered as ROR1-4-BL20E) (5 mg/kg; i.v.; once weekly; 3 doses) achieves 39% tumor growth inhibition in MDA-MB-231 breast cancer xenografts[1].
BL20-MMAE (administered as ROR1-12-BL20E) (5 mg/kg; i.v.) achieves 51% tumor growth inhibition in H1975 non-small cell lung cancer xenografts[1].
BL20-MMAE (administered as ROR1-4-BL20E) (5 mg/kg; i.v.) achieves 69% tumor growth inhibition in H1975 non-small cell lung cancer xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: tumor-bearing mice (implanted with JeKo-1 cells, tumors grown to ~100 mm3)[1]
Dosage: 5 mg/kg
Administration: i.v.; on day 0 and day 4
Result: Achieved a tumor growth inhibition (TGI) rate of 92% in JeKo-1 tumors by day 18, with 1 out of 6 mice showing partial tumor regression.
Resulted in a statistically significant reduction in tumor volume compared to solvent control (P < 0.0001).
Animal Model: tumor-bearing mice (implanted with MDA-MB-231 cells)[1]
Dosage: 5 mg/kg
Administration: i.v.; once weekly; 3 doses
Result: Achieved a tumor growth inhibition (TGI) rate of 49% in MDA-MB-231 tumors.\nAchieved a tumor growth inhibition (TGI) rate of 39% in MDA-MB-231 tumors.
Animal Model: tumor-bearing mice (implanted with H1975 cells, tumors grown to 100-150 mm3)[1]
Dosage: 5 mg/kg
Administration: i.v.
Result: Achieved a tumor growth inhibition (TGI) rate of 51% in H1975 tumors.\nAchieved a tumor growth inhibition (TGI) rate of 69% in H1975 tumors.
Molecular Weight

1963.30

Formula

C98H133F2N13O23S2
CAS No.
SMILES

O=C(N1CCOCC1)C(C=C2)=CC=C2SC(C(N(C3=CC(F)=C(C(F)=C3)OCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N5[C@](CCC5)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)C7=O)=O)=C7SC8=CC=C(C=C8)C(N9CCOCC9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BL20-MMAE Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BL20-MMAE2765612-38-0RORDrug-Linker Conjugates for ADCRAR-related orphan receptorMDA-MB-231 breast cancer xenograftsBL20 linkerH1975 non-small cell lung cancer xenograftsROR1JeKo-1 leukemia xenograftsauristatin payload MMAEInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BL20-MMAE
Cat. No.:
HY-177109
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.