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Cat. No.: HY-160806

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(5-Cl)-Exatecan

(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1-positive cancers.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2813268-66-3
화학식: C₂₄H₂₂ClN₃O₄
분자량:451.90

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

(5-Cl)-Exatecan Chemical Structure

CAS No.: 2813268-66-3

사이즈

가격

재고

수량

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Use of MCE Products

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Camptothecins

All ADC Payloads Isoforms :

All Topoisomerase Isoforms :

In Vitro

(5-Cl)-Exatecan (1-5) can produce ADC compounds that have good targeted killing effects on colon cancer and non-small cell lung cancer (e.g., lung adenocarcinoma)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2813268-66-3
분자량 451.90
화학식 C₂₄H₂₂ClN₃O₄
SMILES

N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(Cl)=C(C)C(CC1)=C62
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

용액&용해도

In Vitro:

DMSO : ≥ 50 mg/mL (110.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2129 mL

11.0644 mL

22.1288 mL

5 mM

0.4426 mL

2.2129 mL

4.4258 mL

10 mM

0.2213 mL

1.1064 mL

2.2129 mL

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tian HJ, et al. Antibody drug conjugate, and preparation method therefor and use thereof. WO2022253035A1. 2022-05-23.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2129 mL	11.0644 mL	22.1288 mL	55.3220 mL
	5 mM	0.4426 mL	2.2129 mL	4.4258 mL	11.0644 mL
	10 mM	0.2213 mL	1.1064 mL	2.2129 mL	5.5322 mL
	15 mM	0.1475 mL	0.7376 mL	1.4753 mL	3.6881 mL
	20 mM	0.1106 mL	0.5532 mL	1.1064 mL	2.7661 mL
	25 mM	0.0885 mL	0.4426 mL	0.8852 mL	2.2129 mL
	30 mM	0.0738 mL	0.3688 mL	0.7376 mL	1.8441 mL
	40 mM	0.0553 mL	0.2766 mL	0.5532 mL	1.3830 mL
	50 mM	0.0443 mL	0.2213 mL	0.4426 mL	1.1064 mL
	60 mM	0.0369 mL	0.1844 mL	0.3688 mL	0.9220 mL
	80 mM	0.0277 mL	0.1383 mL	0.2766 mL	0.6915 mL
	100 mM	0.0221 mL	0.1106 mL	0.2213 mL	0.5532 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
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(5-Cl)-Exatecan

High-Throughput Bioactive Compound Library

All ADC Payloads Isoforms

All Topoisomerase Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

(5-Cl)-Exatecan Related Classifications

HY-160806 Related Classifications