(5-Cl)-Exatecan TFA
(5-Cl)-Exatecan TFA is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan TFA serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan TFA is applicable for the research of ROR1-positive cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H23ClF3N3O6
- 分子量:565.93
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
(5-Cl)-Exatecan TFA TFA (1-5) can produce ADC compounds that have good targeted killing effects on colon cancer and non-small cell lung cancer (e.g., lung adenocarcinoma)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 565.93
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分子式 C26H23ClF3N3O6
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Color White to off-white
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SMILES
N[C@@H]1C2=C3C(C(N4C3)=CC([C@]5(CC)O)=C(C4=O)COC5=O)=NC6=CC(Cl)=C(C(CC1)=C62)C.O=C(O)C(F)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (176.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7670 mL | 8.8350 mL | 17.6700 mL | 44.1751 mL |
| 5 mM | 0.3534 mL | 1.7670 mL | 3.5340 mL | 8.8350 mL | |
| 10 mM | 0.1767 mL | 0.8835 mL | 1.7670 mL | 4.4175 mL | |
| 15 mM | 0.1178 mL | 0.5890 mL | 1.1780 mL | 2.9450 mL | |
| 20 mM | 0.0884 mL | 0.4418 mL | 0.8835 mL | 2.2088 mL | |
| 25 mM | 0.0707 mL | 0.3534 mL | 0.7068 mL | 1.7670 mL | |
| 30 mM | 0.0589 mL | 0.2945 mL | 0.5890 mL | 1.4725 mL | |
| 40 mM | 0.0442 mL | 0.2209 mL | 0.4418 mL | 1.1044 mL | |
| 50 mM | 0.0353 mL | 0.1767 mL | 0.3534 mL | 0.8835 mL | |
| 60 mM | 0.0295 mL | 0.1473 mL | 0.2945 mL | 0.7363 mL | |
| 80 mM | 0.0221 mL | 0.1104 mL | 0.2209 mL | 0.5522 mL | |
| 100 mM | 0.0177 mL | 0.0884 mL | 0.1767 mL | 0.4418 mL |
(5-Cl)-Exatecan TFA 関連分類
HY-160806A 関連分類
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