(5-Cl)-Exatecan TFA
(5-Cl)-Exatecan TFA is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan TFA serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan TFA is applicable for the research of ROR1-positive cancers.
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- Formule: C26H23ClF3N3O6
- Masse moléculaire:565.93
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform ADC Payloads
MoreVoir tous les produits spécifiques à Isoform Topoisomerase
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Activité biologique
Chemical Information
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Appearance Solid
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Masse moléculaire 565.93
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Formule C26H23ClF3N3O6
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Color White to off-white
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SMILES
N[C@@H]1C2=C3C(C(N4C3)=CC([C@]5(CC)O)=C(C4=O)COC5=O)=NC6=CC(Cl)=C(C(CC1)=C62)C.O=C(O)C(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
DMSO : 100 mg/mL (176.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7670 mL | 8.8350 mL | 17.6700 mL | 44.1751 mL |
| 5 mM | 0.3534 mL | 1.7670 mL | 3.5340 mL | 8.8350 mL | |
| 10 mM | 0.1767 mL | 0.8835 mL | 1.7670 mL | 4.4175 mL | |
| 15 mM | 0.1178 mL | 0.5890 mL | 1.1780 mL | 2.9450 mL | |
| 20 mM | 0.0884 mL | 0.4418 mL | 0.8835 mL | 2.2088 mL | |
| 25 mM | 0.0707 mL | 0.3534 mL | 0.7068 mL | 1.7670 mL | |
| 30 mM | 0.0589 mL | 0.2945 mL | 0.5890 mL | 1.4725 mL | |
| 40 mM | 0.0442 mL | 0.2209 mL | 0.4418 mL | 1.1044 mL | |
| 50 mM | 0.0353 mL | 0.1767 mL | 0.3534 mL | 0.8835 mL | |
| 60 mM | 0.0295 mL | 0.1473 mL | 0.2945 mL | 0.7363 mL | |
| 80 mM | 0.0221 mL | 0.1104 mL | 0.2209 mL | 0.5522 mL | |
| 100 mM | 0.0177 mL | 0.0884 mL | 0.1767 mL | 0.4418 mL |
(5-Cl)-Exatecan TFA Related Classifications
HY-160806A Related Classifications
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