2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Payload Topoisomerase
  4. (5-Cl)-Exatecan TFA

(5-Cl)-Exatecan TFA is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan TFA serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan TFA is applicable for the research of ROR1-positive cancers.

For research use only. We do not sell to patients.

(5-Cl)-Exatecan TFA

(5-Cl)-Exatecan TFA Chemical Structure

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Other Forms of (5-Cl)-Exatecan TFA:

(5-Cl)-Exatecan TFA Related Antibodies

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Topoisomerase Topo I Topo II DNA gyrase

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Description

(5-Cl)-Exatecan TFA is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan TFA serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan TFA is applicable for the research of ROR1-positive cancers[1].

In Vitro

(5-Cl)-Exatecan TFA TFA (1-5) can produce ADC compounds that have good targeted killing effects on colon cancer and non-small cell lung cancer (e.g., lung adenocarcinoma)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(5-Cl)-Exatecan TFA Related Antibodies
Molecular Weight

565.93

Formula

C26H23ClF3N3O6
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H]1C2=C3C(C(N4C3)=CC([C@]5(CC)O)=C(C4=O)COC5=O)=NC6=CC(Cl)=C(C(CC1)=C62)C.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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(5-Cl)-Exatecan TFA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(5-Cl)-ExatecanADC PayloadTopoisomeraseADC CytotoxinROR1-positive cancersDNA topoisomeraseInhibitorinhibitorinhibit

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(5-Cl)-Exatecan TFA
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