2. PROTAC Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. PROTACs ROR Apoptosis
  4. PROTAC ROR1 degrader-1

PROTAC ROR1 degrader-1 is a ROR1 PROTAC degrader with DC50 values of 40.88 nM (NCI-H23), 69.0 nM (NCI-H460), 83.35 nM (NCI-H1299) and 42.07 nM (NCI-H1975), respectively. PROTAC ROR1 degrader-1 inhibits the proliferation of lung cancer cells and induces apoptosis. PROTAC ROR1 degrader-1 can be used in research related to non-small cell lung cancer.
(Pink: ROR1 ligand (HY-170996); Blue: VHL ligand (HY-125845); Black: linker (HY-W014787)).

For research use only. We do not sell to patients.

PROTAC ROR1 degrader-1

PROTAC ROR1 degrader-1 Chemical Structure

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PROTAC ROR1 degrader-1 Related Antibodies

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RORγ RORα RORβ

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Description

PROTAC ROR1 degrader-1 is a ROR1 PROTAC degrader with DC50 values of 40.88 nM (NCI-H23), 69.0 nM (NCI-H460), 83.35 nM (NCI-H1299) and 42.07 nM (NCI-H1975), respectively. PROTAC ROR1 degrader-1 inhibits the proliferation of lung cancer cells and induces apoptosis. PROTAC ROR1 degrader-1 can be used in research related to non-small cell lung cancer[1]. (Pink: ROR1 ligand (HY-170996); Blue: VHL ligand (HY-125845); Black: linker (HY-W014787)).

In Vitro

PROTAC ROR1 degrader-1 (Compound 11d) (0.1-1 μM; 24 h) potently degrades ROR1 protein in NCI-H23 non-small cell lung cancer cells. After 24 h of treatment, the degradation rate reaches 93.0% at 0.1 μM and 99.7% at 1 μM[1].
PROTAC ROR1 degrader-1 (1 μM; 4-24 h) induces time-dependent degradation of ROR1 in NCI-H23 non-small cell lung cancer cells. Degradation is detectable at 1 μM within 4 h and reaches the maximum level at 24 h[1].
PROTAC ROR1 degrader-1 (72 h) potently inhibits the proliferation of NCI-H23, NCI-H1975, NCI-H1299 and NCI-H460 non-small cell lung cancer cells, with IC50 values of 0.036 μM, 0.063 μM, 0.164 μM and 0.085 μM respectively after 72 hours of treatment[1].
PROTAC ROR1 degrader-1 (0.1-1.0 μM; 24 h) induces dose-dependent apoptosis in NCI-H23 non-small cell lung cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC ROR1 degrader-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: NCI-H23 non-small cell lung cancer cells
Concentration: 0.1 μM, 1 μM
Incubation Time: 24 h
Result: Achieved ROR1 degradation rates of 93.0% at 0.1 μM and 99.7% at 1 μM after 24-hour treatment.

Western Blot Analysis[1]

Cell Line: NCI-H23 non-small cell lung cancer cells
Concentration: 1 μM
Incubation Time: 4 h, 24 h
Result: Induced ROR1 degradation starting at 4 hours post-treatment, reaching maximal degradation at 24 hours.

Apoptosis Analysis[1]

Cell Line: NCI-H23 non-small cell lung cancer cells
Concentration: 0.1 μM, 0.3 μM, 1.0 μM
Incubation Time: 24 h
Result: Induced dose-dependent apoptosis, with early apoptosis rates of 29.9% (0.1 μM), 46.5% (0.3 μM), and 46.9% (1.0 μM), and corresponding late apoptosis rates of 6.5% (0.1 μM), 20.1% (0.3 μM), and 22.1% (1.0 μM).

Western Blot Analysis[1]

Cell Line: NCI-H23 non-small cell lung cancer cells
Concentration: 0.1 μM, 1 μM
Incubation Time: 10 h
Result: Cleaved PARP at 0.1 μM, while completely activated PARP at 1 μM.
Molecular Weight

1081.22

Formula

C55H74BrN11O5S
SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCC(N2CCN(C3=CC=C(C4=NC5=C(NC6CCN(CC)CC6)C(Br)=CN=C5N4)C=C3)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ROR1 degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ROR1 degrader-1PROTACsRORApoptosisRAR-related orphan receptorNCI-H1975NCI-H1299apoptosisubiquitin proteasome systemnon-small cell lung cancerPARPROR1NCI-H460NCI-H23lung cancer cellsInhibitorinhibitorinhibit

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