DSPE-PEG-Amine, MW 3400 ammonium
Based on 1 Customer Validation
DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 474922-26-4
- Formula: (C2H4O)nN2O10P.NH3
- Molecular Weight:3400 (Average)
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
DSPE-PEG-Amine, MW 3400 ammonium can react with sulfo-NHS-DBCO via an amide bond to form DSPE-PEG-DBCO, and liposomes containing this lipid can successfully target azide-modified A549 tumor cells in vitro through copper-free click chemistry[1].
DSPE-PEG-Amine, MW 3400 ammonium (0.12 mg) can impart a positive surface charge to PLGA-lecithin-PEG core-shell nanoparticles while maintaining an average particle size of approximately 105 nm, which distinguishes them from negatively charged nanoparticles prepared with other DSPE-PEG end groups[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DBCO-liposomes (prepared using DSPE-PEG-Amine, MW 3400 ammonium) can successfully target azide-modified A549 tumors in immunocompetent mice via copper-free click chemistry[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 474922-26-4
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Appearance Solid
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Molecular Weight 3400 (Average)
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Formula (C2H4O)nN2O10P.NH3
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Color White to off-white
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SMILES
O=C(O[C@@H](COP(OCCNC(OCCOCCN)=O)([O-])=O)COC(CCCCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCCCC.[NH4+].[n]
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Synonyms
DSPE-PEG-NH2, MW 3400 ammonium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- DSPE-PEG-Amine, MW 3400
- 474922-26-4
- DSPE-PEG-NH2, MW 3400
- Liposome
- A549 tumor cells
- breast cancer
- nanoparticle surface charge tuning
- DU-145 tumors
- sigma receptor
- copper-free click chemistry
- immunocompetent mice
- inverse electron demand Diels-Alder cycloaddition
- targeted liposome preparation
- nude mouse DU-145 prostate cancer xenograft model
- Inhibitor
- inhibitor
- inhibit