DSPE-PEG-Amine, MW 3400 ammonium  (Synonyms: DSPE-PEG-NH2, MW 3400 ammonium)

DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research^[1][2].

DSPE-PEG-Amine, MW 3400 ammonium can react with sulfo-NHS-DBCO via an amide bond to form DSPE-PEG-DBCO, and liposomes containing this lipid can successfully target azide-modified A549 tumor cells in vitro through copper-free click chemistry^[1].
DSPE-PEG-Amine, MW 3400 ammonium (0.12 mg) can impart a positive surface charge to PLGA-lecithin-PEG core-shell nanoparticles while maintaining an average particle size of approximately 105 nm, which distinguishes them from negatively charged nanoparticles prepared with other DSPE-PEG end groups^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anisamide-conjugated liposomes prepared using DSPE-PEG-Amine, MW 3400 ammonium exhibit favorable in vivo efficacy in nude mouse DU-145 prostate cancer xenograft models^[1].
DBCO-liposomes (prepared using DSPE-PEG-Amine, MW 3400 ammonium) can successfully target azide-modified A549 tumors in immunocompetent mice via copper-free click chemistry^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3400 (Average)

(C₂H₄O)_nN₂O₁₀P.NH₃

474922-26-4

O=C(O[C@@H](COP(OCCNC(OCCOCCN)=O)([O-])=O)COC(CCCCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCCCC.[NH4+].[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Marqués-Gallego P, et al. Ligation strategies for targeting liposomal nanocarriers. Biomed Res Int. 2014;2014:129458.  [Content Brief]

  [2]. ZHENG M, et al. PLGA–Lecithin–PEG core-shell nanoparticles for cancer targeted therapy[J]. Nano Life, 2012, 2(01): 1250002.