2. Metabolic Enzyme/Protease
  3. Liposome
  4. DSPE-PEG2000-SH

DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine.

For research use only. We do not sell to patients.

DSPE-PEG2000-SH

DSPE-PEG2000-SH Chemical Structure

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Based on 1 publication(s) in Google Scholar

DSPE-PEG2000-SH Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine[1].

In Vitro

DSPE-PEG-SH (MW 2000) enables functionalization of SHEDs-derived extracellular vesicles (EVs) with protein conjugates to form SH-EV-protein crosslinkers, which successfully crosslink into hydrogels that maintain uniform protein distribution, although protein conjugation reduces hydrogel storage modulus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DSPE-PEG2000-SH Related Antibodies
In Vivo

Hydrogels crosslinked with extracellular vesicles (EVs) modified by DSPE-PEG-SH, MW 2000 exhibit in vivo stability equivalent to PEG-SH-crosslinked hydrogels over a one-week subcutaneous implantation period[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2000 (Average)

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCC(OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCS)=O)=O)=O)=O.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 8.33 mg/mL (ultrasonic and warming and heat to 60°C)

H2O : 8.33 mg/mL (ultrasonic and warming and heat to 60°C)

DMSO : 6.67 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation

Purity: 99.82%

SDS (251 KB)

COA (240 KB) HNMR (312 KB) RP-HPLC (217 KB)

Handling Instructions (2659 KB)
References
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DSPE-PEG2000-SH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSPE-PEG2000-SHLiposomehydrogelsthiol-ene photochemistryextracellular vesicle bilayer membranesHUVECextracellular vesiclesmMSCsVEGF8-arm PEG-norbornenesubcutaneous implantationSHEDs-derived EV membranesInhibitorinhibitorinhibit

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