DSPE-PEG2000-Mannose
Based on 1 publication(s) in Google Scholar
DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume.
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- Pureté : 90.0%
- CAS No.: 1829524-73-3
- Masse moléculaire:2000 (Average)
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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PEG2000-DMPEMicelle Raw Material
Publications Citing Use of MedChemExpress (MCE) DSPE-PEG2000-Mannose
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Activité biologique
Description
In Vitro
DSPE-PEG2000-Mannose (3:10:10:4 molar ratio with DOTAP, DPPC, cholesterol; 10 min hydration, 10 min post-extrusion incubation) was used to prepare mannose-conjugated liposomes (Man-lipo) for siRNA delivery, with formulation steps including lipid mixing, hydration with siRNA-protamine mixture, vortexing, sonication, extrusion, and post-extrusion incubation[1].
DSPE-PEG2000-Mannose-formulated Man-lipo-siIDO (24 h post-transfection) significantly reduced IDO mRNA levels in mouse bone marrow-derived dendritic cells (DCs) compared to Man-lipo-siScramble control[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1829524-73-3
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Appearance Solid
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Masse moléculaire 2000 (Average)
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(OCCOCCNC(NC1=CC=C(O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=S)=O)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[n]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
In Vitro:
DMSO : 16.67 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 10 mg/mL (Need ultrasonic)
Protocole
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG2000-Mannose Related Classifications
HY-168374 Related Classifications
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