897383-62-9
897383-62-9
Chemical Structure
Allitinib
Synonym(s): AST-1306; ALS 1306
- CAS No.: 897383-62-9
- Formula:C24H18ClFN4O2
- Molecular Weight:448.88
IUPAC Name: N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)acrylamide
InChIKey: MVZGYPSXNDCANY-UHFFFAOYSA-N
SMILES: FC1=CC=CC(COC2=C(Cl)C=C(NC3=NC=NC4=C3C=C(NC(C=C)=O)C=C4)C=C2)=C1
Biological Activity: Allitinib (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib is an anilino-quinazoline compound and has anti-cancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Allitinib | 98.88% | Allitinib (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib is an anilino-quinazoline compound and has anti-cancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-13427Allitinib tosylate -
Similarity Score 0.79
HY-W010778N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine -
Similarity Score 0.72
HY-177379EGFR ligand-14 -
Similarity Score 0.71
HY-159047EGFR ligand-10 -
Similarity Score 0.71
HY-116059EGFR-IN-199 -
Similarity Score 0.68
HY-164489KU004 -
Similarity Score 0.66
HY-116091EGFR-IN-451 -
Similarity Score 0.65
HY-125084NEU617 -
Similarity Score 0.65
HY-13896PD168393 -
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