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Cat. No.: HY-116059

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EGFR-IN-199

EGFR-IN-199 is a selective and potent EGFR inhibitor with IC₅₀ values of 1.1 nM and 1.4 nM for purified EGFR WT and EGFR^T790M/L858R kinases. EGFR-IN-199 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 1639040-91-7
Formula: C₂₆H₂₀FN₅O
Molecular Weight:437.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-199 Chemical Structure

CAS No.: 1639040-91-7

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

EGFR

1.1 nM (IC₅₀)

EGFR^L858R/T790M

1.4 nM (IC₅₀)

All EGFR Isoforms :

In Vitro

EGFR-IN-199 (Compound C3) potently inhibits purified EGFR WT and EGFR^T790M/L858R kinases with IC₅₀ values of 1.1 nM and 1.4 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1639040-91-7
Molecular Weight 437.47
Formula C₂₆H₂₀FN₅O
SMILES

C=CC(NC1=CC2=C(N=CN=C2C=C1)NC3=CC4=C(C=C3)N(C=C4)CC5=CC=CC(F)=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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