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Cat. No.: HY-116059

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EGFR-IN-199

EGFR-IN-199 is a selective and potent EGFR inhibitor with IC₅₀ values of 1.1 nM and 1.4 nM for purified EGFR WT and EGFR^T790M/L858R kinases. EGFR-IN-199 can be used for the research of cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1639040-91-7
화학식: C₂₆H₂₀FN₅O
분자량:437.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-199 Chemical Structure

CAS No.: 1639040-91-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

EGFR

1.1 nM (IC₅₀)

EGFR^L858R/T790M

1.4 nM (IC₅₀)

All EGFR Isoforms :

In Vitro

EGFR-IN-199 (Compound C3) potently inhibits purified EGFR WT and EGFR^T790M/L858R kinases with IC₅₀ values of 1.1 nM and 1.4 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1639040-91-7
분자량 437.47
화학식 C₂₆H₂₀FN₅O
SMILES

C=CC(NC1=CC2=C(N=CN=C2C=C1)NC3=CC4=C(C=C3)N(C=C4)CC5=CC=CC(F)=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
Species:
Purity:
수량:

EGFR-IN-199

All EGFR Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EGFR-IN-199 Related Classifications

HY-116059 Related Classifications

Bioz

Keywords

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