EGFR-IN-199
EGFR-IN-199 is a selective and potent EGFR inhibitor with IC50 values of 1.1 nM and 1.4 nM for purified EGFR WT and EGFRT790M/L858R kinases. EGFR-IN-199 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1639040-91-7
- Formula: C26H20FN5O
- Molecular Weight:437.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
EGFR 1.1 nM (IC50) |
EGFRL858R/T790M 1.4 nM (IC50) |
In Vitro
EGFR-IN-199 (Compound C3) potently inhibits purified EGFR WT and EGFRT790M/L858R kinases with IC50 values of 1.1 nM and 1.4 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1639040-91-7
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Molecular Weight 437.47
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Formula C26H20FN5O
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SMILES
C=CC(NC1=CC2=C(N=CN=C2C=C1)NC3=CC4=C(C=C3)N(C=C4)CC5=CC=CC(F)=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-199 Related Classifications
HY-116059 Related Classifications
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