1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Autophagy
  2. EGFR
    Autophagy

PD168393 (Synonyms: PD-168393; PD 168393)

Cat. No.: HY-13896 Purity: 98.28%
Data Sheet SDS Handling Instructions

PD168393 is an potent, cell-permeable, irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773, inactive against insulin, PDGFR, FGFR and PKC.

For research use only. We do not sell to patients.
PD168393 Chemical Structure

PD168393 Chemical Structure

CAS No. : 194423-15-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $57 In-stock
2 mg $50 In-stock
5 mg $70 In-stock
10 mg $120 In-stock
25 mg $240 In-stock
50 mg $420 In-stock
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Description

PD168393 is an potent, cell-permeable, irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773, inactive against insulin, PDGFR, FGFR and PKC. target: EGFR IC 50: 0.7 nM [1] (1) PD 168393 inhibite EGFr autophosphorylation in A431 human epidermoid carcinoma cells with >9-fold greater potency than PD 174265.[1] (2) PD 168393 decrease the production of TNF-α and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes.[2] (3) PD168393 completely inhibits AKT and ERK phosphorylation at concentrations as low as 0.03 umol/L.[3] (4) PD168393 could induce apoptosis and inhibit cell growth in ErbB2 positive lung and breast cancer cell lines.[3] (5) PD168393 disrupted MEK1/p44/42 ERK signaling in HaCaT cells as determined by inhibition of phospho-p44/42 ERK. [4]

References
M.Wt

369.22

Formula

C₁₇H₁₃BrN₄O

CAS No.

194423-15-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PD168393
Cat. No.:
HY-13896
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