194423-15-9
194423-15-9
Chemical Structure
PD168393
- CAS No.: 194423-15-9
- Formula:C17H13BrN4O
- Molecular Weight:369.22
IUPAC Name: N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide
InChIKey: HTUBKQUPEREOGA-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
Biological Activity: PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PD168393 | 98.01% | PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.89
HY-112411PD 174265 -
Similarity Score 0.87
HY-10325RCL-387785 (Standard) -
Similarity Score 0.78
HY-116091EGFR-IN-451 -
Similarity Score 0.76
HY-144676pan-HER-IN-1 -
Similarity Score 0.74
HY-18609PD158780 -
Similarity Score 0.73
HY-183909EphB1-IN-2 -
Similarity Score 0.71
HY-14346PD153035 -
Similarity Score 0.71
HY-12013PD153035 Hydrochloride -
Similarity Score 0.69
HY-103437EGFR-IN-80 -
Explore the MedChemAI to find more analogs
