1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Apoptosis
  2. EGFR
    Apoptosis
  3. pan-HER-IN-1

pan-HER-IN-1 

Cat. No.: HY-144676
Handling Instructions

pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities.

For research use only. We do not sell to patients.

pan-HER-IN-1 Chemical Structure

pan-HER-IN-1 Chemical Structure

CAS No. : 1639040-94-0

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Description

pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].

IC50 & Target

EGFR

0.38 nM (IC50)

HER4

1.6 nM (IC50)

EGFRL858R/T790M/C797S

2.2 nM (IC50)

HER2

3.5 nM (IC50)

Molecular Weight

408.25

Formula

C19H14BrN5O

CAS No.
SMILES

C=CC(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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