pan-HER-IN-1
pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities.
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- CAS. Nr.: 1639040-94-0
- Formel: C19H14BrN5O
- Molecular Weight:408.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Alle EGFR Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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EGFR 0.38 nM (IC50) |
HER4 1.6 nM (IC50) |
EGFRL858R/T790M/C797S 2.2 nM (IC50) |
HER2 3.5 nM (IC50) |
Chemical Information
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CAS. Nr. 1639040-94-0
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Molecular Weight 408.25
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Formel C19H14BrN5O
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SMILES
C=CC(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
pan-HER-IN-1 Related Classifications
HY-144676 Related Classifications
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