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Erlotinib Hydrochloride

(Synonyms: CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride)
143 Cited Publications
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Based on 143 publication(s) in Google Scholar

Erlotinib (CP-358774) Hydrochloride is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib Hydrochloride also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib Hydrochloride blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib Hydrochloride inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib Hydrochloride is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib Hydrochloride can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis.

For research use only. We do not sell to patients.

  • Purity: 99.94%
  • CAS No.: 183319-69-9
  • Formula: C22H24ClN3O4
  • Molecular Weight:429.90
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Erlotinib Hydrochloride Chemical Structure
    Erlotinib Hydrochloride Chemical Structure
  • Experimental Validation Results for Erlotinib Hydrochloride
  • Experimental Validation Results for Erlotinib Hydrochloride
  • Experimental Validation Results for Erlotinib Hydrochloride
  • Experimental Validation Results for Erlotinib Hydrochloride
  • Experimental Validation Results for Erlotinib Hydrochloride
  • Experimental Validation Results for Erlotinib Hydrochloride
CAS No.: 183319-69-9
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Erlotinib Hydrochloride Chemical Structure
    Erlotinib Hydrochloride Chemical Structure
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    Erlotinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Med. 2024 May;13(10):e7083. [Abstract]

    Customer Validation
     FACS analysis was used to perform the MFI of cell membrane of PD‐L1 in H441 cells with control or multiply small molecular inhibitors (Seen in the Table 1, 24 h) (n = 3). AV412 (HY‐10346; 20, 50 nM), ERK1/2 inhibitor 1 (HY‐112287; 20, 50 nM), AR‐A014418 (HY‐10512; 100, 200 nM), Erlotinib (HY‐50896; 50, 100 nM).

  • 1/16

    Erlotinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Med. 2019 Dec;8(18):7793-7808. [Abstract]

    Customer Validation
     Western blots of proteins expression in EGFR signaling pathways in LN229 and U87 cells with MYST1/GFP overexpression after erlotinib (200 ng/mL)/DMSO treatment.

  • 1/16

    Erlotinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Anal Chim Acta. 2018 Nov 22:1032:138-146. [Abstract]

    Customer Validation
     30 min after EGF(100 ng/mL) and EGFP-sSH2(Arg)9 (5 μM) are added into the MDA-MB-468 cell culture medium, Erlotinib is added into the cell culture medium (100 nM), and the picture was collected at 30 min after Erlotinib treatment.

  • 1/16

    Erlotinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jun 21:9:660. [Abstract]

    Customer Validation
     By Western blotting, the α-SMA and palladin proteins are determined in cells that are pretreated with NF-κB (JSH-23), Wnt/β-catenin (XAV939), EGFR (erlotinib), p38 MAPK (TAK-715), and Smad3 (SIS3) inhibitors and are followed by TWEAK stimulation.

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    Erlotinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2018 Mar;12(3):305-321. [Abstract]

    Customer Validation
     Western blot analysis of total and phosphorylated EGFR expression in two breast cancer cells pretreated with different concentration Erlotinib for 4h.

  • 1/16

    Erlotinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2017 May 11;36(19):2643-2654. [Abstract]

    Customer Validation
     Effects of anti-cancer agents Oxaliplatin, Erlotinib (25 μM) and cAMP inducer Forskolin (25 μM) on FOXO3 expression in Panc-1 cells are assessed for 72 h (n=3).

  • Erlotinib Hydrochloride