KU004
KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative.
For research use only. We do not sell to patients.
- CAS No.: 1260401-93-1
- Formula: C29H27ClFN4O2P
- Molecular Weight:548.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 1260401-93-1
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Molecular Weight 548.98
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Formula C29H27ClFN4O2P
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SMILES
ClC1=C(OCC2=CC(F)=CC=C2)C=CC(NC3=NC=NC4=CC=C(C#CCN5CCP(CC5)(C)=O)C=C43)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tian C, et al. A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells. Apoptosis. 2015 Dec;20(12):1599-612. [Content Brief]
[2]. Tian C, et al. Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer. Exp Cell Res. 2017 Aug 15;357(2):211-221. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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