1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR/ErbB-2/ErbB-4 inhibitor-2

EGFR/ErbB-2/ErbB-4 inhibitor-2 

Cat. No.: HY-112420 Purity: 99.69%
Handling Instructions

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM.

For research use only. We do not sell to patients.

EGFR/ErbB-2/ErbB-4 inhibitor-2 Chemical Structure

EGFR/ErbB-2/ErbB-4 inhibitor-2 Chemical Structure

CAS No. : 179248-61-4

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
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25 mg USD 1100 In-stock
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50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM[1].

IC50 & Target[1]

EGFR

0.017 μM (IC50)

ErbB2

0.08 μM (IC50)

ErbB4

1.91 μM (IC50)

In Vitro

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

387.43

Formula

C₂₃H₂₁N₃O₃

CAS No.
SMILES

COC1=CC2=NC=NC(NC3=CC=C(OCC4=CC=CC=C4)C=C3)=C2C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

EGFR/ErbB-2/ErbB-4 inhibitor-2EGFREpidermal growth factor receptorErbB-1HER1HN5ErbB2ErbB4Inhibitorinhibitorinhibit

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Product Name:
EGFR/ErbB-2/ErbB-4 inhibitor-2
Cat. No.:
HY-112420
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