1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Olmutinib

Olmutinib (Synonyms: HM61713, BI 1482694)

Cat. No.: HY-19730 Purity: 99.95%
Handling Instructions

Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.

For research use only. We do not sell to patients.

Olmutinib Chemical Structure

Olmutinib Chemical Structure

CAS No. : 1353550-13-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 336 In-stock
Estimated Time of Arrival: December 31
200 mg USD 540 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Top Publications Citing Use of Products

    Olmutinib purchased from MCE. Usage Cited in: Acta Pharm Sin B. 2018 Jul;8(4):563-574.

    The protein levels of ABCG2 in MDR cells after different concentrations Olmutinib stimulation for 48 h are measured by Western blot analysis (GAPDH as loading control).
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.

    IC50 & Target

    IC50: 9.2 nM (HCC827) and 10 nM (H1975) [1]

    In Vitro

    Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].

    Clinical Trial
    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 44 mg/mL (90.43 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0551 mL 10.2756 mL 20.5512 mL
    5 mM 0.4110 mL 2.0551 mL 4.1102 mL
    10 mM 0.2055 mL 1.0276 mL 2.0551 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    486.59

    Formula

    C₂₆H₂₆N₆O₂S

    CAS No.

    1353550-13-6

    SMILES

    C=CC(NC1=CC=CC(OC2=C3C(C=CS3)=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    Olmutinib
    Cat. No.:
    HY-19730
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    Olmutinib

    Cat. No.: HY-19730