Cat. No.: HY-168438

ERBB agonist-1

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ERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC₅₀ of 10.5 μM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H₂O₂-induced cardiomyocyte death and Ang II (HY-13948)-induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models.

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Pureté: 99.16%
CAS No.: 930856-19-2
Formule: C₂₄H₂₅N₃O₂S
Masse moléculaire:419.54

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ERBB agonist-1 Chemical Structure

CAS No.: 930856-19-2

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Chemical Information

CAS No. 930856-19-2
Appearance Solid
Masse moléculaire 419.54
Formule C₂₄H₂₅N₃O₂S
Color White to off-white
SMILES

O=C(NC1CC1)C(SC(N2C3CCCC3)=NC4=CC=CC=C4C2=O)C5=CC=CC=C5
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Stem Cells

LARP7 enhances the potential of dental pulp stem cells to promote peripheral nerve repair. [Abstract]

2026 Mar 11:sxag013. PMID: 41812059

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (238.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3836 mL

11.9178 mL

23.8356 mL

5 mM

0.4767 mL

2.3836 mL

4.7671 mL

10 mM

0.2384 mL

1.1918 mL

2.3836 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cools JMT, et al., Small-molecule-induced ERBB4 activation to treat heart failure. Nat Commun. 2025 Jan 10;16(1):576. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3836 mL	11.9178 mL	23.8356 mL	59.5891 mL
	5 mM	0.4767 mL	2.3836 mL	4.7671 mL	11.9178 mL
	10 mM	0.2384 mL	1.1918 mL	2.3836 mL	5.9589 mL
	15 mM	0.1589 mL	0.7945 mL	1.5890 mL	3.9726 mL
	20 mM	0.1192 mL	0.5959 mL	1.1918 mL	2.9795 mL
	25 mM	0.0953 mL	0.4767 mL	0.9534 mL	2.3836 mL
	30 mM	0.0795 mL	0.3973 mL	0.7945 mL	1.9863 mL
	40 mM	0.0596 mL	0.2979 mL	0.5959 mL	1.4897 mL
	50 mM	0.0477 mL	0.2384 mL	0.4767 mL	1.1918 mL
	60 mM	0.0397 mL	0.1986 mL	0.3973 mL	0.9932 mL
	80 mM	0.0298 mL	0.1490 mL	0.2979 mL	0.7449 mL
	100 mM	0.0238 mL	0.1192 mL	0.2384 mL	0.5959 mL

Keywords

ERBB agonist-1

1 Cited Publications

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ERBB agonist-1

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Publications Citing Use of MedChemExpress (MCE) ERBB agonist-1

Voir tous les produits spécifiques à Isoform EGFR

Voir tous les produits spécifiques à Isoform Akt

Voir tous les produits spécifiques à Isoform ERK

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

ERBB agonist-1 Related Classifications

HY-168438 Related Classifications