2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  4. EGF Superfamily Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases
  5. EGFR/ErbB family
  6. ErbB4/HER4
  7. HER4 Protein, Rat (HEK293, Fc)

HER4 Protein, Rat (HEK293, Fc)

Cat. No.: HY-P73036
Handling Instructions

HER4 Protein, crucial in central nervous system development, influences neural crest cell migration and axon guidance. Additionally, it participates in mammary gland differentiation, inducing milk proteins and contributing to lactation. HER4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HER4 Protein, Rat (HEK293, Fc) is 626 a.a., with molecular weight of ~119 kDa.

For research use only. We do not sell to patients.

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Description

HER4 Protein, crucial in central nervous system development, influences neural crest cell migration and axon guidance. Additionally, it participates in mammary gland differentiation, inducing milk proteins and contributing to lactation. HER4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HER4 Protein, Rat (HEK293, Fc) is 626 a.a., with molecular weight of ~119 kDa.
Background

ERBB4 is a protein that plays important roles in the development of the central nervous system, neural crest cell migration, and axon guidance. It is also involved in mammary gland differentiation, induction of milk proteins, and lactation.
Species

Rat
Source

HEK293
Tag

C-hFc
Accession

Q62956 (Q26-P651)
Gene ID
Molecular Construction
N-term
HER4 (Q26-P651)
Accession # Q62956
hFc
C-term
Synonyms
Receptor tyrosine-protein kinase erbB-4; 4ICD; E4ICD; s80HER4; ERBB4; HER4
AA Sequence

MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTP

Molecular Weight

Approximately 119 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

HER4 Protein, Rat (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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