1. GPCR/G Protein
  2. Urotensin Receptor
  3. Urotensin II (114-124), human TFA

Urotensin II (114-124), human TFA 

Cat. No.: HY-P1164A Purity: 99.76%
COA Handling Instructions

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

For research use only. We do not sell to patients.

Urotensin II (114-124), human TFA Chemical Structure

Urotensin II (114-124), human TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 170 In-stock
5 mg USD 680 In-stock
10 mg USD 1088 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Urotensin II (114-124), human TFA:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

IC50 & Target

GPR14[1]

In Vitro

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1502.59

Formula

C66H86F3N13O20S2

Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)

Sequence Shortening

ETPDCFWKYCV (Disulfide bridge: Cys5-Cys7)

SMILES

O=C(N[C@H]1CC2=CNC3=C2C=CC=C3)[C@H](CC4=CC=CC=C4)NC([C@@]([H])(NC([C@@H](NC([C@H]5N(C([C@@H](NC([C@H](CCC(O)=O)N)=O)[C@@H](C)O)=O)CCC5)=O)CC(O)=O)=O)CSSC[C@H](NC([C@@H](NC([C@@]([H])(NC1=O)CCCCN)=O)CC6=CC=C(C=C6)O)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (66.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6655 mL 3.3276 mL 6.6552 mL
5 mM 0.1331 mL 0.6655 mL 1.3310 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (66.55 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6655 mL 3.3276 mL 6.6552 mL 16.6379 mL
5 mM 0.1331 mL 0.6655 mL 1.3310 mL 3.3276 mL
10 mM 0.0666 mL 0.3328 mL 0.6655 mL 1.6638 mL
15 mM 0.0444 mL 0.2218 mL 0.4437 mL 1.1092 mL
20 mM 0.0333 mL 0.1664 mL 0.3328 mL 0.8319 mL
25 mM 0.0266 mL 0.1331 mL 0.2662 mL 0.6655 mL
30 mM 0.0222 mL 0.1109 mL 0.2218 mL 0.5546 mL
40 mM 0.0166 mL 0.0832 mL 0.1664 mL 0.4159 mL
50 mM 0.0133 mL 0.0666 mL 0.1331 mL 0.3328 mL
60 mM 0.0111 mL 0.0555 mL 0.1109 mL 0.2773 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Urotensin II (114-124), human TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Urotensin II (114-124), human TFA
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HY-P1164A
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