2. GPCR/G Protein
  3. Urotensin Receptor
  4. Urotensin II (114-124), human TFA

Urotensin II (114-124), human TFA 

Cat. No.: HY-P1164A Purity: 99.76%
COA Handling Instructions

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Urotensin II (114-124), human TFA Chemical Structure

Urotensin II (114-124), human TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 170 In-stock
Estimated Time of Arrival: December 31
5 mg USD 680 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Urotensin II (114-124), human TFA:

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Description

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

IC50 & Target

GPR14[1]
In Vitro

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1502.59

Appearance

Solid

Formula

C66H86F3N13O20S2
Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)
Sequence Shortening

ETPDCFWKYCV (Disulfide bridge: Cys5-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (66.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6655 mL 3.3276 mL 6.6552 mL
5 mM 0.1331 mL 0.6655 mL 1.3310 mL
10 mM 0.0666 mL 0.3328 mL 0.6655 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (66.55 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.76%

COA (258 KB) RP-HPLC (144 KB) MS (152 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Urotensin II (114-124), humanUrotensin ReceptorUT receptorInhibitorinhibitorinhibit

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