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MLS0315771 

Cat. No.: HY-112945 Purity: 98.68%
Handling Instructions

MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.

For research use only. We do not sell to patients.

MLS0315771 Chemical Structure

MLS0315771 Chemical Structure

CAS No. : 727664-91-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 520 In-stock
Estimated Time of Arrival: December 31
100 mg USD 690 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.

IC50 & Target

IC50: ~1 μM (MPI)[1].

In Vitro

MLS0315771 increases mannose flux toward glycosylation.
MLS0315771 toxicity at higher concentrations is an off-target effect.
MLS0315771 is toxic to the zebrafish embryos above 2 μM. At 8-10 μM, ~50% embryos appeare sick within 20 min, and most of them die by 30-60 min[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6586 mL 18.2929 mL 36.5858 mL
5 mM 0.7317 mL 3.6586 mL 7.3172 mL
10 mM 0.3659 mL 1.8293 mL 3.6586 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

273.33

Formula

C₁₅H₁₂FNOS

CAS No.

727664-91-7

SMILES

FC1=CC=C2C(SN(C3=C(C)C=CC(C)=C3)C2=O)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
MLS0315771
Cat. No.:
HY-112945
Quantity:

MLS0315771

Cat. No.: HY-112945