UPG-108
UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR). UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system.
For research use only. We do not sell to patients.
- CAS No.: 3090686-88-4
- Formula: C65H88N14O17S2
- Molecular Weight:1401.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 3090686-88-4
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Molecular Weight 1401.61
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Formula C65H88N14O17S2
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Sequence
Glu-Thr-Pro-Glu-Asp-{Pen}-Phe-{d-Trp}-{Orn}-Tyr-Cys-Val (Disulfide bridge: Pen-Cys)
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Sequence Shortening
ETPED-{Pen}-F-{d-Trp}-{Orn}-YCV (Disulfide bridge: Pen-Cys)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UPG-108 Related Classifications
Cat. No.: HY-P11258
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- UPG-108
- 3090686-88-4
- UPG108
- UPG 108
- Urotensin Receptor
- Urotensin II receptor (UTR)
- Super-agonist
- Positive allosteric modulator (PAM)
- Lateral allostery
- GPCR multimer
- Structure-activity relationship (SAR)
- N-terminal peptide engineering
- Noncompetitive modulation
- Calcium mobilization
- Rat aorta contraction
- Inhibitor
- inhibitor
- inhibit