UPG-108
UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR). UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system.
For research use only. We do not sell to patients.
- CAS No.: 3090686-88-4
- Formula: C65H88N14O17S2
- Molecular Weight:1401.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 3090686-88-4
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Molecular Weight 1401.61
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Formula C65H88N14O17S2
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Sequence
Glu-Thr-Pro-Glu-Asp-{Pen}-Phe-{d-Trp}-{Orn}-Tyr-Cys-Val (Disulfide bridge: Pen-Cys)
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Sequence Shortening
ETPED-{Pen}-F-{d-Trp}-{Orn}-YCV (Disulfide bridge: Pen-Cys)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca2+]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca2+ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UPG-108 Related Classifications
HY-P11258 Related Classifications
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Keywords
- UPG-108
- 3090686-88-4
- UPG108
- UPG 108
- Urotensin Receptor
- Urotensin II receptor (UTR)
- Super-agonist
- Positive allosteric modulator (PAM)
- Lateral allostery
- GPCR multimer
- Structure-activity relationship (SAR)
- N-terminal peptide engineering
- Noncompetitive modulation
- Calcium mobilization
- Rat aorta contraction
- Inhibitor
- inhibitor
- inhibit