1. GPCR/G Protein
  2. Urotensin Receptor
  3. Urotensin II, mouse

Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system.

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Urotensin II, mouse Chemical Structure

Urotensin II, mouse Chemical Structure

CAS No. : 405137-01-1

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Description

Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system[1].

IC50 & Target

GPR14[1]

In Vitro

This sequence of the C-terminus cyclic region of Urotensin II (U-II) is completely conserved in most species, including in the fish, frog, human, porcine, rat, and mouse, and it is thought to be essential for the agonistic activity of U-II. Urotensin II plays a physiological role in the central nervous system. Intracerebroventricular administration of Urotensin II induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner, as do corticotropin releasing factor (CRF). The effective doses of Urotensin II are 10-100-fold higher than these of CRF in these tests[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Urotensin II is a somatostatin-like cyclic peptide which functions as an arterial vasocontrictor, vasodilator, and bronchoconstriction mediator[1].
Urotensin II (0.1 nmol, 0.3 nmol, and 3 nmol; intracerebroventricular administration) induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6N mice (8 weeks old)[1]
Dosage: 0.1 nmol, 0.3 nmol, and 3 nmol
Administration: Intracerebroventricular (i.c.v.) administration
Result: Decreased the amount of head dipping without significant alteration of the motor activity.
Molecular Weight

1633.85

Formula

C76H100N18O19S2

CAS No.
Sequence

{pGlu}-His-Gly-Ala-Ala-Pro-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Ile (Disulfide bridge: Cys8-Cys13)

Sequence Shortening

{pGlu}-HGAAPECFWKYCI (Disulfide bridge: Cys8-Cys13)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Urotensin II, mouse Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Urotensin II, mouse
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HY-P1483
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