Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM.
For research use only. We do not sell to patients.
- CAS No.: 131791-98-5
- Formula: C64H88N10O26S
- Molecular Weight:1445.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 131791-98-5
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Molecular Weight 1445.50
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Formula C64H88N10O26S
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Sequence
{Suc-Phe}-Glu-Pro-Ile-Pro-Glu-Glu-{Tyr(SO3H)}-Leu-{d-Glu}
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Sequence Shortening
{Suc-Phe}-EPIPEE-{Tyr(SO3H)}-L-{d-Glu}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. [Content Brief]
[2]. Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) Related Classifications
HY-P4721 Related Classifications
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