131791-98-5
Chemical Structure
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
- CAS No.: 131791-98-5
- Formula:C64H88N10O26S
- Molecular Weight:1445.50
InChIKey: QKQRTIWHVSBBQC-FQSUHZHRSA-N
SMILES: O=C([C@H]1N(CCC1)C([C@H](CCC(O)=O)NC([C@@H](NC(CCC(O)=O)=O)CC2=CC=CC=C2)=O)=O)N[C@@H]([C@@H](C)CC)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(O)=O)CCC(O)=O)=O)=O)CC4=CC=C(C=C4)OS(=O)(O)=O)=O)=O)=O)=O
Biological Activity: Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].
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Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) | Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM. | |||||||||||||||||||||
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References
- [1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. [Content Brief]
