1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. Vorapaxar sulfate

Vorapaxar sulfate (Synonyms: SCH 530348 sulfate)

Cat. No.: HY-10119A
Handling Instructions

Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.

For research use only. We do not sell to patients.

Vorapaxar sulfate Chemical Structure

Vorapaxar sulfate Chemical Structure

CAS No. : 705260-08-8

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Top Publications Citing Use of Products

    Vorapaxar sulfate purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Jul 9;11(7):520.

    Expression of PAR1, YAP, and TAZ is assessed by Western blotting. Vorapaxar efficiently blocks the expression of YAP and TAZ in T47D-Twist and MDA-MB-231 cells.
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    Description

    Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner[1].

    IC50 & Target

    Ki: 8.1 nM (PAR-1)[1]

    In Vitro

    Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    590.66

    Formula

    C₂₉H₃₅FN₂O₈S

    CAS No.

    705260-08-8

    SMILES

    O=C(O[[email protected]@H]1C)[[email protected]@]2([H])[[email protected]]1([H])[[email protected]@H](/C=C/C3=NC=C(C=C3)C4=CC=CC(F)=C4)[[email protected]]([[email protected]](C5)([H])C2)([H])CC[[email protected]]5NC(OCC)=O.O=S(O)(O)=O

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    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    VorapaxarSCH 530348SCH530348SCH-530348Protease-Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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    Vorapaxar sulfate
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