2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Vorapaxar sulfate

Vorapaxar sulfate  (Synonyms: SCH 530348 sulfate)

Cat. No.: HY-10119A Purity: 99.40%
COA Handling Instructions

Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.

For research use only. We do not sell to patients.

Vorapaxar sulfate Chemical Structure

Vorapaxar sulfate Chemical Structure

CAS No. : 705260-08-8

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1 mg USD 42 In-stock
5 mg USD 90 In-stock
10 mg USD 150 In-stock
50 mg USD 450 In-stock
100 mg USD 750 In-stock
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Vorapaxar sulfate:

Vorapaxar sulfate Related Antibodies

Top Publications Citing Use of Products

    Vorapaxar sulfate purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Jul 9;11(7):520.  [Abstract]

    Expression of PAR1, YAP, and TAZ is assessed by Western blotting. Vorapaxar efficiently blocks the expression of YAP and TAZ in T47D-Twist and MDA-MB-231 cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner[1].

    IC50 & Target

    PAR1

     

    In Vitro

    Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Vorapaxar sulfate Related Antibodies
    Clinical Trial
    Molecular Weight

    590.66

    Appearance

    Solid

    Formula

    C29H35FN2O8S
    CAS No.
    SMILES

    O=C(O[C@@H]1C)[C@@]2([H])[C@]1([H])[C@@H](/C=C/C3=NC=C(C=C3)C4=CC=CC(F)=C4)[C@]([C@](C5)([H])C2)([H])CC[C@H]5NC(OCC)=O.O=S(O)(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (211.63 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6930 mL 8.4651 mL 16.9302 mL
    5 mM 0.3386 mL 1.6930 mL 3.3860 mL
    10 mM 0.1693 mL 0.8465 mL 1.6930 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (3.52 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (3.52 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Vorapaxar sulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Vorapaxar705260-08-8SCH 530348SCH530348SCH-530348Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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